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Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design.
La CC, Smith SA, Vappala S, Adili R, Luke CE, Abbina S, Luo HD, Chafeeva I, Drayton M, Creagh LA, de Guadalupe Jaraquemada-Peláez M, Rhoads N, Kalathottukaren MT, Henke PK, Straus SK, Du C, Conway EM, Holinstat M, Haynes CA, Morrissey JH, Kizhakkedathu JN. La CC, et al. Among authors: vappala s. Nat Commun. 2023 Apr 26;14(1):2177. doi: 10.1038/s41467-023-37709-0. Nat Commun. 2023. PMID: 37100783 Free PMC article.
DNASE-MEDIATED DISSOLUTION OF NEUTROPHIL EXTRACELLULAR TRAPS ACCELERATES IN VITRO THROMBIN GENERATION KINETICS IN TRAUMA PATIENTS.
Goswami J, MacArthur TA, Mahony C, Kizhakkedathu JN, Vappala S, Smith S, Morrissey JH, Spears GM, Bailey KR, Dong JF, Kozar RA, Hall N, Johnstone A, Park MS. Goswami J, et al. Among authors: vappala s. Shock. 2022 Sep 1;58(3):217-223. doi: 10.1097/SHK.0000000000001972. Epub 2022 Aug 8. Shock. 2022. PMID: 35959777 Free PMC article.
Development of a High-Throughput Urosepsis Mouse Model.
Herout R, Vappala S, Hanstock S, Moskalev I, Chew BH, Kizhakkedathu JN, Lange D. Herout R, et al. Among authors: vappala s. Pathogens. 2023 Apr 15;12(4):604. doi: 10.3390/pathogens12040604. Pathogens. 2023. PMID: 37111490 Free PMC article.
Inhibitors of Polyphosphate and Neutrophil Extracellular Traps.
Vappala S, Smith SA, Kizhakkedathu JN, Morrissey JH. Vappala S, et al. Semin Thromb Hemost. 2023 May 16:10.1055/s-0043-1768936. doi: 10.1055/s-0043-1768936. Online ahead of print. Semin Thromb Hemost. 2023. PMID: 37192652