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Rare genetic coding variants associated with human longevity and protection against age-related diseases.
Lin JR, Sin-Chan P, Napolioni V, Torres GG, Mitra J, Zhang Q, Jabalameli MR, Wang Z, Nguyen N, Gao T; Regeneron Genetics Center; Laudes M, Görg S, Franke A, Nebel A, Greicius MD, Atzmon G, Ye K, Gorbunova V, Ladiges WC, Shuldiner AR, Niedernhofer LJ, Robbins PD, Milman S, Suh Y, Vijg J, Barzilai N, Zhang ZD. Lin JR, et al. Among authors: gorg s. Nat Aging. 2021 Sep;1(9):783-794. doi: 10.1038/s43587-021-00108-5. Epub 2021 Sep 13. Nat Aging. 2021. PMID: 37117627
Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score.
Torres GG, Dose J, Hasenbein TP, Nygaard M, Krause-Kyora B, Mengel-From J, Christensen K, Andersen-Ranberg K, Kolbe D, Lieb W, Laudes M, Görg S, Schreiber S, Franke A, Caliebe A, Kuhlenbäumer G, Nebel A. Torres GG, et al. Among authors: gorg s. Int J Mol Sci. 2022 Sep 19;23(18):10949. doi: 10.3390/ijms231810949. Int J Mol Sci. 2022. PMID: 36142858 Free PMC article.
Development of a high-resolution NGS-based HLA-typing and analysis pipeline.
Wittig M, Anmarkrud JA, Kässens JC, Koch S, Forster M, Ellinghaus E, Hov JR, Sauer S, Schimmler M, Ziemann M, Görg S, Jacob F, Karlsen TH, Franke A. Wittig M, et al. Among authors: gorg s. Nucleic Acids Res. 2015 Jun 23;43(11):e70. doi: 10.1093/nar/gkv184. Epub 2015 Mar 9. Nucleic Acids Res. 2015. PMID: 25753671 Free PMC article.
Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases.
Recke A, Vidarsson G, Ludwig RJ, Freitag M, Möller S, Vonthein R, Schellenberger J, Haase O, Görg S, Nebel A, Flachsbart F, Schreiber S, Lieb W, Gläser R, Benoit S, Sárdy M, Eming R, Hertl M, Zillikens D, König IR, Schmidt E, Ibrahim S; German AIBD Genetic Study Group. Recke A, et al. Among authors: gorg s. J Autoimmun. 2015 Jul;61:36-44. doi: 10.1016/j.jaut.2015.05.004. Epub 2015 May 29. J Autoimmun. 2015. PMID: 26032265
High-throughput method for the hybridisation-based targeted enrichment of long genomic fragments for PacBio third-generation sequencing.
Steiert TA, Fuß J, Juzenas S, Wittig M, Hoeppner MP, Vollstedt M, Varkalaite G, ElAbd H, Brockmann C, Görg S, Gassner C, Forster M, Franke A. Steiert TA, et al. Among authors: gorg s. NAR Genom Bioinform. 2022 Jul 13;4(3):lqac051. doi: 10.1093/nargab/lqac051. eCollection 2022 Sep. NAR Genom Bioinform. 2022. PMID: 35855323 Free PMC article.
GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level.
Schröder J, Chegwidden L, Maj C, Gehlen J, Speller J, Böhmer AC, Borisov O, Hess T, Kreuser N, Venerito M, Alakus H, May A, Gerges C, Schmidt T, Thieme R, Heider D, Hillmer AM, Reingruber J, Lyros O, Dietrich A, Hoffmeister A, Mehdorn M, Lordick F, Stocker G, Hohaus M, Reim D, Kandler J, Müller M, Ebigbo A, Fuchs C, Bruns CJ, Hölscher AH, Lang H, Grimminger PP, Dakkak D, Vashist Y, May S, Görg S, Franke A, Ellinghaus D, Galavotti S, Veits L, Weismüller J, Dommermuth J, Benner U, Rösch T, Messmann H, Schumacher B, Neuhaus H, Schmidt C, Wissinowski TT, Nöthen MM; Wellcome Trust Case Control Consortium 2 (WTCCC2); Esophageal Adenocarcinoma Genetics Consortium (EAGLE); Barrett's and Esophageal Adenocarcinoma Consortium (BEACON); Dong J, Ong JS, Buas MF, Thrift AP, Vaughan TL, Tomlinson I, Whiteman DC, Fitzgerald RC, Jankowski J, Vieth M, Mayr A, Gharahkhani P, MacGregor S, Gockel I, Palles C, Schumacher J. Schröder J, et al. Among authors: gorg s. Gut. 2023 Apr;72(4):612-623. doi: 10.1136/gutjnl-2021-326698. Epub 2022 Jul 26. Gut. 2023. PMID: 35882562
52 results