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Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice.
Hedges CP, Shetty B, Broome SC, MacRae C, Koutsifeli P, Buckels EJ, MacIndoe C, Boix J, Tsiloulis T, Matthews BG, Sinha S, Arendse M, Jaiswal JK, Mellor KM, Hickey AJR, Shepherd PR, Merry TL. Hedges CP, et al. Among authors: hickey ajr. Nat Aging. 2023 Feb;3(2):162-172. doi: 10.1038/s43587-022-00349-y. Epub 2023 Jan 23. Nat Aging. 2023. PMID: 37118113
Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.
Gu Y, Chang TT, Wang J, Jaiswal JK, Edwards D, Downes NJ, Liyanage HDS, Lynch CRH, Pruijn FB, Hickey AJR, Hay MP, Wilson WR, Hicks KO. Gu Y, et al. Among authors: hickey ajr. Front Pharmacol. 2017 Aug 11;8:531. doi: 10.3389/fphar.2017.00531. eCollection 2017. Front Pharmacol. 2017. PMID: 28848445 Free PMC article.
Exercise recovery increases skeletal muscle H2O2 emission and mitochondrial respiratory capacity following two-weeks of limb immobilization.
Pileggi CA, Hedges CP, D'Souza RF, Durainayagam BR, Markworth JF, Hickey AJR, Mitchell CJ, Cameron-Smith D. Pileggi CA, et al. Among authors: hickey ajr. Free Radic Biol Med. 2018 Aug 20;124:241-248. doi: 10.1016/j.freeradbiomed.2018.06.012. Epub 2018 Jun 15. Free Radic Biol Med. 2018. PMID: 29909291 Clinical Trial.
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