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Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice.
Hedges CP, Shetty B, Broome SC, MacRae C, Koutsifeli P, Buckels EJ, MacIndoe C, Boix J, Tsiloulis T, Matthews BG, Sinha S, Arendse M, Jaiswal JK, Mellor KM, Hickey AJR, Shepherd PR, Merry TL. Hedges CP, et al. Among authors: macrae c. Nat Aging. 2023 Feb;3(2):162-172. doi: 10.1038/s43587-022-00349-y. Epub 2023 Jan 23. Nat Aging. 2023. PMID: 37118113
Daily protein supplementation attenuates immobilization-induced blunting of postabsorptive muscle mTORC1 activation in middle-aged men.
Zeng N, D'Souza RF, MacRae CL, Figueiredo VC, Pileggi CA, Markworth JF, Merry TL, Cameron-Smith D, Mitchell CJ. Zeng N, et al. Among authors: macrae cl. Am J Physiol Cell Physiol. 2021 Apr 1;320(4):C591-C601. doi: 10.1152/ajpcell.00284.2020. Epub 2021 Jan 20. Am J Physiol Cell Physiol. 2021. PMID: 33471625 Free article. Clinical Trial.
Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans.
Rael VE, Yano JA, Huizar JP, Slayden LC, Weiss MA, Turcotte EA, Terry JM, Zuo W, Thiffault I, Pastinen T, Farrow EG, Jenkins JL, Becker ML, Wong SC, Stevens AM, Otten C, Allenspach EJ, Bonner DE, Bernstein JA, Wheeler MT, Saxton RA; Undiagnosed Diseases Network; Liu B, Majer O, Barton GM. Rael VE, et al. J Exp Med. 2024 Aug 5;221(8):e20232005. doi: 10.1084/jem.20232005. Epub 2024 May 23. J Exp Med. 2024. PMID: 38780621 Free PMC article.
Personalized Intervention Based on Early Detection of Atherosclerosis: JACC State-of-the-Art Review.
Nielsen RV, Fuster V, Bundgaard H, Fuster JJ, Johri AM, Kofoed KF, Douglas PS, Diederichsen A, Shapiro MD, Nicholls SJ, Nordestgaard BG, Lindholt JS, MacRae C, Yuan C, Newby DE, Urbina EM, Bergström G, Ridderstråle M, Budoff MJ, Bøttcher M, Raitakari OT, Hansen TH, Näslund U, Sillesen H, Eldrup N, Ibanez B. Nielsen RV, et al. Among authors: macrae c. J Am Coll Cardiol. 2024 May 28;83(21):2112-2127. doi: 10.1016/j.jacc.2024.02.053. J Am Coll Cardiol. 2024. PMID: 38777513 Review.
Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease.
Linna-Kuosmanen S, Schmauch E, Galani K, Ojanen J, Boix CA, Örd T, Toropainen A, Singha PK, Moreau PR, Harju K, Blazeski A, Segerstolpe Å, Lahtinen V, Hou L, Kang K, Meibalan E, Agudelo LZ, Kokki H, Halonen J, Jalkanen J, Gunn J, MacRae CA, Hollmén M, Hartikainen JEK, Kaikkonen MU, García-Cardeña G, Tavi P, Kiviniemi T, Kellis M. Linna-Kuosmanen S, et al. Among authors: macrae ca. Cell Rep Med. 2024 May 21;5(5):101556. doi: 10.1016/j.xcrm.2024.101556. Cell Rep Med. 2024. PMID: 38776872 Free PMC article.
637 results