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Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy.
Boccanegra B, Cappellari O, Mantuano P, Trisciuzzi D, Mele A, Tulimiero L, De Bellis M, Cirmi S, Sanarica F, Cerchiara AG, Conte E, Meanti R, Rizzi L, Bresciani E, Denoyelle S, Fehrentz JA, Cruciani G, Nicolotti O, Liantonio A, Torsello A, De Luca A. Boccanegra B, et al. Among authors: denoyelle s. Front Immunol. 2023 Apr 12;14:1119888. doi: 10.3389/fimmu.2023.1119888. eCollection 2023. Front Immunol. 2023. PMID: 37122711 Free PMC article.
Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region.
Barrile F, M'Kadmi C, De Francesco PN, Cabral A, García Romero G, Mustafá ER, Cantel S, Damian M, Mary S, Denoyelle S, Banères JL, Marie J, Raingo J, Fehrentz JA, Perelló M. Barrile F, et al. Among authors: denoyelle s. Mol Cell Endocrinol. 2019 Dec 1;498:110573. doi: 10.1016/j.mce.2019.110573. Epub 2019 Sep 6. Mol Cell Endocrinol. 2019. PMID: 31499133
Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms.
Uriarte M, De Francesco PN, Fernández G, Castrogiovanni D, D'Arcangelo M, Imbernon M, Cantel S, Denoyelle S, Fehrentz JA, Praetorius J, Prevot V, Perello M. Uriarte M, et al. Among authors: denoyelle s. Mol Cell Endocrinol. 2021 Dec 1;538:111449. doi: 10.1016/j.mce.2021.111449. Epub 2021 Aug 31. Mol Cell Endocrinol. 2021. PMID: 34478806
N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor.
M'Kadmi C, Cabral A, Barrile F, Giribaldi J, Cantel S, Damian M, Mary S, Denoyelle S, Dutertre S, Péraldi-Roux S, Neasta J, Oiry C, Banères JL, Marie J, Perello M, Fehrentz JA. M'Kadmi C, et al. Among authors: denoyelle s. J Med Chem. 2019 Jan 24;62(2):965-973. doi: 10.1021/acs.jmedchem.8b01644. Epub 2018 Dec 24. J Med Chem. 2019. PMID: 30543423
New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.
Blayo AL, Maingot M, Aicher B, M'Kadmi C, Schmidt P, Müller G, Teifel M, Günther E, Gagne D, Denoyelle S, Martinez J, Fehrentz JA. Blayo AL, et al. Among authors: denoyelle s. Bioorg Med Chem Lett. 2015 Jan 1;25(1):20-4. doi: 10.1016/j.bmcl.2014.11.031. Epub 2014 Nov 15. Bioorg Med Chem Lett. 2015. PMID: 25435152
GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
Fernandez G, Cabral A, De Francesco PN, Uriarte M, Reynaldo M, Castrogiovanni D, Zubiría G, Giovambattista A, Cantel S, Denoyelle S, Fehrentz JA, Tolle V, Schiöth HB, Perello M. Fernandez G, et al. Among authors: denoyelle s. Cell Mol Life Sci. 2022 May 4;79(5):277. doi: 10.1007/s00018-022-04302-5. Cell Mol Life Sci. 2022. PMID: 35504998 Free PMC article.
Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.
M'Kadmi C, Leyris JP, Onfroy L, Galés C, Saulière A, Gagne D, Damian M, Mary S, Maingot M, Denoyelle S, Verdié P, Fehrentz JA, Martinez J, Banères JL, Marie J. M'Kadmi C, et al. Among authors: denoyelle s. J Biol Chem. 2015 Nov 6;290(45):27021-27039. doi: 10.1074/jbc.M115.659250. Epub 2015 Sep 11. J Biol Chem. 2015. PMID: 26363071 Free PMC article.
27 results