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Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.
Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A. Papsdorf K, et al. Among authors: brunet a. Nat Cell Biol. 2023 May;25(5):672-684. doi: 10.1038/s41556-023-01136-6. Epub 2023 May 1. Nat Cell Biol. 2023. PMID: 37127715 Free PMC article.
FOXO flips the longevity SWItch.
Webb AE, Brunet A. Webb AE, et al. Among authors: brunet a. Nat Cell Biol. 2013 May;15(5):444-6. doi: 10.1038/ncb2749. Nat Cell Biol. 2013. PMID: 23636422
H3K4me3 breadth is linked to cell identity and transcriptional consistency.
Benayoun BA, Pollina EA, Ucar D, Mahmoudi S, Karra K, Wong ED, Devarajan K, Daugherty AC, Kundaje AB, Mancini E, Hitz BC, Gupta R, Rando TA, Baker JC, Snyder MP, Cherry JM, Brunet A. Benayoun BA, et al. Among authors: brunet a. Cell. 2014 Jul 31;158(3):673-88. doi: 10.1016/j.cell.2014.06.027. Cell. 2014. PMID: 25083876 Free PMC article.
Bursts of Reprogramming: A Path to Extend Lifespan?
Mahmoudi S, Brunet A. Mahmoudi S, et al. Among authors: brunet a. Cell. 2016 Dec 15;167(7):1672-1674. doi: 10.1016/j.cell.2016.11.050. Cell. 2016. PMID: 27984716 Free PMC article.
Dynamic landscape and regulation of RNA editing in mammals.
Tan MH, Li Q, Shanmugam R, Piskol R, Kohler J, Young AN, Liu KI, Zhang R, Ramaswami G, Ariyoshi K, Gupte A, Keegan LP, George CX, Ramu A, Huang N, Pollina EA, Leeman DS, Rustighi A, Goh YPS; GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group; Statistical Methods groups—Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site—NDRI; Biospecimen Collection Source Site—RPCI; Biospecimen Core Resource—VARI; Brain Bank Repository—University of Miami Brain Endowment Bank; Leidos Biomedical—Project Management; ELSI Study; Genome Browser Data Integration &Visualization—EBI; Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz; Chawla A, Del Sal G, Peltz G, Brunet A, Conrad DF, Samuel CE, O'Connell MA, Walkley CR, Nishikura K, Li JB. Tan MH, et al. Among authors: brunet a. Nature. 2017 Oct 11;550(7675):249-254. doi: 10.1038/nature24041. Nature. 2017. PMID: 29022589 Free PMC article.
Linking Lipid Metabolism to Chromatin Regulation in Aging.
Papsdorf K, Brunet A. Papsdorf K, et al. Among authors: brunet a. Trends Cell Biol. 2019 Feb;29(2):97-116. doi: 10.1016/j.tcb.2018.09.004. Epub 2018 Oct 10. Trends Cell Biol. 2019. PMID: 30316636 Free PMC article. Review.
Turning back time with emerging rejuvenation strategies.
Mahmoudi S, Xu L, Brunet A. Mahmoudi S, et al. Among authors: brunet a. Nat Cell Biol. 2019 Jan;21(1):32-43. doi: 10.1038/s41556-018-0206-0. Epub 2019 Jan 2. Nat Cell Biol. 2019. PMID: 30602763 Free PMC article. Review.
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prélot L, Ang CE, Shibuya Y, Benayoun BA, Chang ALS, Wernig M, Wysocka J, Longaker MT, Snyder MP, Brunet A. Mahmoudi S, et al. Among authors: brunet a. Nature. 2019 Oct;574(7779):553-558. doi: 10.1038/s41586-019-1658-5. Epub 2019 Oct 23. Nature. 2019. PMID: 31645721 Free PMC article.
616 results