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Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.
Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A. Papsdorf K, et al. Among authors: miklas jw. Nat Cell Biol. 2023 May;25(5):672-684. doi: 10.1038/s41556-023-01136-6. Epub 2023 May 1. Nat Cell Biol. 2023. PMID: 37127715 Free PMC article.
Amino acid primed mTOR activity is essential for heart regeneration.
Miklas JW, Levy S, Hofsteen P, Mex DI, Clark E, Muster J, Robitaille AM, Sivaram G, Abell L, Goodson JM, Pranoto I, Madan A, Chin MT, Tian R, Murry CE, Moon RT, Wang Y, Ruohola-Baker H. Miklas JW, et al. iScience. 2021 Dec 6;25(1):103574. doi: 10.1016/j.isci.2021.103574. eCollection 2022 Jan 21. iScience. 2021. PMID: 34988408 Free PMC article.
Support cells in the brain promote longevity.
Miklas JW, Brunet A. Miklas JW, et al. Science. 2020 Jan 24;367(6476):365-366. doi: 10.1126/science.aba4474. Science. 2020. PMID: 31974234 Free PMC article. No abstract available.
Long life depends on open communication.
Miklas JW, Brunet A. Miklas JW, et al. Nat Cell Biol. 2022 Jun;24(6):808-810. doi: 10.1038/s41556-022-00908-w. Nat Cell Biol. 2022. PMID: 35681007 Free PMC article.
Males induce premature demise of the opposite sex by multifaceted strategies.
Booth LN, Shi C, Tantilert C, Yeo RW, Miklas JW, Hebestreit K, Hollenhorst CN, Maures TJ, Buckley MT, Murphy CT, Brunet A. Booth LN, et al. Among authors: miklas jw. Nat Aging. 2022 Sep;2(9):809-823. doi: 10.1038/s43587-022-00276-y. Epub 2022 Sep 16. Nat Aging. 2022. PMID: 37118502 Free PMC article.
Author Correction: Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.
Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A. Papsdorf K, et al. Among authors: miklas jw. Nat Cell Biol. 2023 Oct;25(10):1547. doi: 10.1038/s41556-023-01220-x. Nat Cell Biol. 2023. PMID: 37567997 Free PMC article. No abstract available.
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes.
Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H. Miklas JW, et al. Nat Commun. 2019 Oct 11;10(1):4671. doi: 10.1038/s41467-019-12482-1. Nat Commun. 2019. PMID: 31604922 Free PMC article.
Author Correction: TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes.
Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H. Miklas JW, et al. Nat Commun. 2020 May 8;11(1):2387. doi: 10.1038/s41467-020-16186-9. Nat Commun. 2020. PMID: 32385292 Free PMC article.
Metabolic Control over mTOR-Dependent Diapause-like State.
Hussein AM, Wang Y, Mathieu J, Margaretha L, Song C, Jones DC, Cavanaugh C, Miklas JW, Mahen E, Showalter MR, Ruzzo WL, Fiehn O, Ware CB, Blau CA, Ruohola-Baker H. Hussein AM, et al. Among authors: miklas jw. Dev Cell. 2020 Jan 27;52(2):236-250.e7. doi: 10.1016/j.devcel.2019.12.018. Dev Cell. 2020. PMID: 31991105 Free PMC article.
23 results