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Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.
Berard AR, Brubaker DK, Birse K, Lamont A, Mackelprang RD, Noël-Romas L, Perner M, Hou X, Irungu E, Mugo N, Knodel S, Muwonge TR, Katabira E, Hughes SM, Levy C, Calienes FL, Lauffenburger DA, Baeten JM, Celum C, Hladik F, Lingappa J, Burgener AD. Berard AR, et al. Among authors: lingappa j. Cell Rep. 2023 May 30;42(5):112474. doi: 10.1016/j.celrep.2023.112474. Epub 2023 May 6. Cell Rep. 2023. PMID: 37149863 Free PMC article.
Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection.
Hughes SM, Levy CN, Calienes FL, Stekler JD, Pandey U, Vojtech L, Berard AR, Birse K, Noël-Romas L, Richardson B, Golden JB, Cartwright M, Collier AC, Stevens CE, Curlin ME, Holtz TH, Mugo N, Irungu E, Katabira E, Muwonge T, Lama JR, Baeten JM, Burgener A, Lingappa JR, McElrath MJ, Mackelprang R, McGowan I, Cranston RD, Cameron MJ, Hladik F. Hughes SM, et al. Among authors: lingappa jr. Cell Rep Med. 2020 Sep 22;1(6):100096. doi: 10.1016/j.xcrm.2020.100096. Cell Rep Med. 2020. PMID: 33015651 Free PMC article.
Brief Report: Bacterial Vaginosis and Risk of HIV Infection in the Context of CD101 Gene Variation.
Wanga V, Mackelprang RD, Thomas KK, Donnell D, Cohen CR, Mugo NR, Bukusi EA, de Bruyn G, Irungu E, Celum C, Baeten JM, Lingappa JR; Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study. Wanga V, et al. J Acquir Immune Defic Syndr. 2020 Dec 15;85(5):584-587. doi: 10.1097/QAI.0000000000002505. J Acquir Immune Defic Syndr. 2020. PMID: 32976203 Free PMC article.
CD101 genetic variants modify regulatory and conventional T cell phenotypes and functions.
Richert-Spuhler LE, Mar CM, Shinde P, Wu F, Hong T, Greene E, Hou S, Thomas K, Gottardo R, Mugo N, de Bruyn G, Celum C, Baeten JM, Lingappa JR, Lund JM; Partners in Prevention HSV/HIV Transmission Study; and the Partners PrEP Study Teams. Richert-Spuhler LE, et al. Cell Rep Med. 2021 Jun 15;2(6):100322. doi: 10.1016/j.xcrm.2021.100322. eCollection 2021 Jun 15. Cell Rep Med. 2021. PMID: 34195685 Free PMC article.
Upregulation of IFN-stimulated genes persists beyond the transitory broad immunologic changes of acute HIV-1 infection.
Mackelprang RD, Filali-Mouhim A, Richardson B, Lefebvre F, Katabira E, Ronald A, Gray G, Cohen KW, Klatt NR, Pecor T, Celum C, McElrath MJ, Hughes SM, Hladik F, Cameron MJ, Lingappa JR; Partners in Prevention HSV/HIV Transmission Study; Partners PrEP Study Teams. Mackelprang RD, et al. Among authors: lingappa jr. iScience. 2023 Mar 21;26(4):106454. doi: 10.1016/j.isci.2023.106454. eCollection 2023 Apr 21. iScience. 2023. PMID: 37020953 Free PMC article.
Efficacy of oral pre-exposure prophylaxis (PrEP) for HIV among women with abnormal vaginal microbiota: a post-hoc analysis of the randomised, placebo-controlled Partners PrEP Study.
Heffron R, McClelland RS, Balkus JE, Celum C, Cohen CR, Mugo N, Bukusi E, Donnell D, Lingappa J, Kiarie J, Fiedler T, Munch M, Fredricks DN, Baeten JM; Partners PrEP Study Team. Heffron R, et al. Among authors: lingappa j. Lancet HIV. 2017 Oct;4(10):e449-e456. doi: 10.1016/S2352-3018(17)30110-8. Epub 2017 Jul 18. Lancet HIV. 2017. PMID: 28732773 Free PMC article. Clinical Trial.
Evaluation of the association between the concentrations of key vaginal bacteria and the increased risk of HIV acquisition in African women from five cohorts: a nested case-control study.
McClelland RS, Lingappa JR, Srinivasan S, Kinuthia J, John-Stewart GC, Jaoko W, Richardson BA, Yuhas K, Fiedler TL, Mandaliya KN, Munch MM, Mugo NR, Cohen CR, Baeten JM, Celum C, Overbaugh J, Fredricks DN. McClelland RS, et al. Among authors: lingappa jr. Lancet Infect Dis. 2018 May;18(5):554-564. doi: 10.1016/S1473-3099(18)30058-6. Epub 2018 Jan 26. Lancet Infect Dis. 2018. PMID: 29396006 Free PMC article.
Mycobacterium tuberculosis-Specific T-Cell Responses Are Impaired During Late Pregnancy With Elevated Biomarkers of Tuberculosis Risk Postpartum.
Saha A, Escuduero J, Layouni T, Richardson B, Hou S, Mugo N, Mujugira A, Celum C, Baeten JM, Lingappa J, John-Stewart GC, LaCourse SM, Shah JA. Saha A, et al. Among authors: lingappa j. J Infect Dis. 2022 May 4;225(9):1663-1674. doi: 10.1093/infdis/jiab614. J Infect Dis. 2022. PMID: 34929030 Free PMC article. Clinical Trial.
198 results