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Chemical probes of histone lysine methyltransferases.
Kaniskan HÜ, Jin J. Kaniskan HÜ, et al. ACS Chem Biol. 2015 Jan 16;10(1):40-50. doi: 10.1021/cb500785t. Epub 2014 Nov 25. ACS Chem Biol. 2015. PMID: 25423077 Free PMC article. Review.
Inhibitors of Protein Methyltransferases and Demethylases.
Kaniskan HÜ, Martini ML, Jin J. Kaniskan HÜ, et al. Chem Rev. 2018 Feb 14;118(3):989-1068. doi: 10.1021/acs.chemrev.6b00801. Epub 2017 Mar 24. Chem Rev. 2018. PMID: 28338320 Free PMC article. Review.
A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects.
Pryce KD, Kang HJ, Sakloth F, Liu Y, Khan S, Toth K, Kapoor A, Nicolais A, Che T, Qin L, Bertherat F, Kaniskan HÜ, Jin J, Cameron MD, Roth BL, Zachariou V, Filizola M. Pryce KD, et al. Among authors: kaniskan hu. Neuropharmacology. 2021 Sep 1;195:108673. doi: 10.1016/j.neuropharm.2021.108673. Epub 2021 Jun 18. Neuropharmacology. 2021. PMID: 34153316 Free PMC article.
Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer's Disease, healthspan and lifespan- Aging as a consequence of glycolysis.
Litke R, Vicari J, Huang BT, Shapiro L, Roh KH, Silver A, Talreja P, Palacios N, Yoon Y, Kellner C, Kaniskan H, Vangeti S, Jin J, Ramos-Lopez I, Mobbs C. Litke R, et al. bioRxiv [Preprint]. 2023 Oct 1:2023.06.12.544352. doi: 10.1101/2023.06.12.544352. bioRxiv. 2023. PMID: 37398396 Free PMC article. Preprint.
Discovery of the First-in-class G9a/GLP PROTAC Degrader.
Velez J, Han Y, Yim H, Yang P, Deng Z, Park KS, Kabir M, Kaniskan HÜ, Xiong Y, Jin J. Velez J, et al. Among authors: kaniskan hu. bioRxiv [Preprint]. 2024 Feb 29:2024.02.26.582210. doi: 10.1101/2024.02.26.582210. bioRxiv. 2024. PMID: 38464025 Free PMC article. Updated. Preprint.
Selective inhibitors of protein methyltransferases.
Kaniskan HÜ, Konze KD, Jin J. Kaniskan HÜ, et al. J Med Chem. 2015 Feb 26;58(4):1596-629. doi: 10.1021/jm501234a. Epub 2014 Dec 2. J Med Chem. 2015. PMID: 25406853 Free PMC article.
54 results