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A common mechanism of Sec61 translocon inhibition by small molecules.
Nat Chem Biol. 2023 Sep;19(9):1063-1071. doi: 10.1038/s41589-023-01337-y. Epub 2023 May 11.
Nat Chem Biol. 2023.
PMID: 37169959
Mechanism of Protein Translocation by the Sec61 Translocon Complex.
Itskanov S, Park E.
Itskanov S, et al.
Cold Spring Harb Perspect Biol. 2023 Jan 3;15(1):a041250. doi: 10.1101/cshperspect.a041250.
Cold Spring Harb Perspect Biol. 2023.
PMID: 35940906
Review.
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Structure of the posttranslational Sec protein-translocation channel complex from yeast.
Itskanov S, Park E.
Itskanov S, et al.
Science. 2019 Jan 4;363(6422):84-87. doi: 10.1126/science.aav6740. Epub 2018 Dec 13.
Science. 2019.
PMID: 30545845
Free PMC article.
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Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
Itskanov S, Kuo KM, Gumbart JC, Park E.
Itskanov S, et al.
Nat Struct Mol Biol. 2021 Feb;28(2):162-172. doi: 10.1038/s41594-020-00541-x. Epub 2021 Jan 4.
Nat Struct Mol Biol. 2021.
PMID: 33398175
Free PMC article.
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Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10.
Wu K, Itskanov S, Lynch DL, Chen Y, Turner A, Gumbart JC, Park E.
Wu K, et al. Among authors: itskanov s.
Nat Commun. 2024 Mar 11;15(1):2182. doi: 10.1038/s41467-024-46409-2.
Nat Commun. 2024.
PMID: 38467638
Free PMC article.
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Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10.
Wu K, Itskanov S, Lynch DL, Chen Y, Turner A, Gumbart JC, Park E.
Wu K, et al. Among authors: itskanov s.
bioRxiv [Preprint]. 2024 Jan 9:2024.01.09.574907. doi: 10.1101/2024.01.09.574907.
bioRxiv. 2024.
PMID: 38260251
Free PMC article.
Updated.
Preprint.
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The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.
Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B.
Böhler P, et al. Among authors: itskanov s.
Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8.
Cell Death Dis. 2018.
PMID: 29459714
Free PMC article.
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