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Page 1
Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial.
Huttunen HJ, Booms S, Sjögren M, Kerstens V, Johansson J, Holmnäs R, Koskinen J, Kulesskaya N, Fazio P, Woolley M, Brady A, Williams J, Johnson D, Dailami N, Gray W, Levo R, Saarma M, Halldin C, Marjamaa J, Resendiz-Nieves J, Grubor I, Lind G, Eerola-Rautio J, Mertsalmi T, Andréasson M, Paul G, Rinne J, Kivisaari R, Bjartmarz H, Almqvist P, Varrone A, Scheperjans F, Widner H, Svenningsson P. Huttunen HJ, et al. Among authors: saarma m. Mov Disord. 2023 Jul;38(7):1209-1222. doi: 10.1002/mds.29426. Epub 2023 May 22. Mov Disord. 2023. PMID: 37212361 Clinical Trial.
CDNF and ER stress: Pharmacology and therapeutic possibilities.
Lõhelaid H, Saarma M, Airavaara M. Lõhelaid H, et al. Among authors: saarma m. Pharmacol Ther. 2024 Feb;254:108594. doi: 10.1016/j.pharmthera.2024.108594. Epub 2024 Jan 28. Pharmacol Ther. 2024. PMID: 38290651 Free article. Review.
MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α.
Kovaleva V, Yu LY, Ivanova L, Shpironok O, Nam J, Eesmaa A, Kumpula EP, Sakson S, Toots U, Ustav M, Huiskonen JT, Voutilainen MH, Lindholm P, Karelson M, Saarma M. Kovaleva V, et al. Among authors: saarma m. Cell Rep. 2023 Feb 28;42(2):112066. doi: 10.1016/j.celrep.2023.112066. Epub 2023 Feb 3. Cell Rep. 2023. PMID: 36739529 Free article.
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.
Moliner R, Girych M, Brunello CA, Kovaleva V, Biojone C, Enkavi G, Antenucci L, Kot EF, Goncharuk SA, Kaurinkoski K, Kuutti M, Fred SM, Elsilä LV, Sakson S, Cannarozzo C, Diniz CRAF, Seiffert N, Rubiolo A, Haapaniemi H, Meshi E, Nagaeva E, Öhman T, Róg T, Kankuri E, Vilar M, Varjosalo M, Korpi ER, Permi P, Mineev KS, Saarma M, Vattulainen I, Casarotto PC, Castrén E. Moliner R, et al. Among authors: saarma m. Nat Neurosci. 2023 Jun;26(6):1032-1041. doi: 10.1038/s41593-023-01316-5. Epub 2023 Jun 5. Nat Neurosci. 2023. PMID: 37280397 Free PMC article.
CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress.
De Lorenzo F, Lüningschrör P, Nam J, Beckett L, Pilotto F, Galli E, Lindholm P, Rüdt von Collenberg C, Mungwa ST, Jablonka S, Kauder J, Thau-Habermann N, Petri S, Lindholm D, Saxena S, Sendtner M, Saarma M, Voutilainen MH. De Lorenzo F, et al. Among authors: saarma m. Brain. 2023 Sep 1;146(9):3783-3799. doi: 10.1093/brain/awad087. Brain. 2023. PMID: 36928391 Free PMC article.
Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage.
Tseng KY, Stratoulias V, Hu WF, Wu JS, Wang V, Chen YH, Seelbach A, Huttunen HJ, Kulesskaya N, Pang CY, Chou JL, Lindahl M, Saarma M, Huang LC, Airavaara M, Liew HK. Tseng KY, et al. Among authors: saarma m. Cell Death Dis. 2023 Feb 15;14(2):128. doi: 10.1038/s41419-022-05520-2. Cell Death Dis. 2023. PMID: 36792604 Free PMC article.
The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte-Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity.
Caglayan AB, Beker MC, Sertel Evren E, Caglayan B, Kilic Ü, Ates N, Caglayan A, Dasdelen MF, Doeppner TR, Saarma M, Hermann DM, Kilic E. Caglayan AB, et al. Among authors: saarma m. Transl Stroke Res. 2023 Apr;14(2):263-277. doi: 10.1007/s12975-022-01035-2. Epub 2022 May 18. Transl Stroke Res. 2023. PMID: 35583716
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL.
Chow CFW, Guo X, Asthana P, Zhang S, Wong SKK, Fallah S, Che S, Gurung S, Wang Z, Lee KB, Ge X, Yuan S, Xu H, Ip JPK, Jiang Z, Zhai L, Wu J, Zhang Y, Mahato AK, Saarma M, Lin CY, Kwan HY, Huang T, Lyu A, Zhou Z, Bian ZX, Wong HLX. Chow CFW, et al. Among authors: saarma m. Nat Metab. 2022 Feb;4(2):203-212. doi: 10.1038/s42255-022-00529-5. Epub 2022 Feb 17. Nat Metab. 2022. PMID: 35177851
298 results