Al-Ramahi I - Search Results

1

Tau polarizes an aging transcriptional signature to excitatory neurons and glia.

Wu T, Deger JM, Ye H, Guo C, Dhindsa J, Pekarek BT, Al-Ouran R, Liu Z, Al-Ramahi I, Botas J, Shulman JM. Wu T, et al. Among authors: al ramahi i. Elife. 2023 May 23;12:e85251. doi: 10.7554/eLife.85251. Elife. 2023. PMID: 37219079 Free PMC article.

2

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.

Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY. Rousseaux MW, et al. Elife. 2016 Oct 25;5:e19809. doi: 10.7554/eLife.19809. Elife. 2016. PMID: 27779468 Free PMC article.

3

Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.

Onur TS, Laitman A, Zhao H, Keyho R, Kim H, Wang J, Mair M, Wang H, Li L, Perez A, de Haro M, Wan YW, Allen G, Lu B, Al-Ramahi I, Liu Z, Botas J. Onur TS, et al. Elife. 2021 Apr 19;10:e64564. doi: 10.7554/eLife.64564. Elife. 2021. PMID: 33871358 Free PMC article.

4

[No title available]

[No authors listed] [No authors listed] PMID: 34971159

5

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.

Yao Y, Cui X, Al-Ramahi I, Sun X, Li B, Hou J, Difiglia M, Palacino J, Wu ZY, Ma L, Botas J, Lu B. Yao Y, et al. Elife. 2015 Mar 4;4:e05449. doi: 10.7554/eLife.05449. Elife. 2015. PMID: 25738228 Free PMC article.

6

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ. Al-Ramahi I, et al. Elife. 2017 Dec 26;6:e29123. doi: 10.7554/eLife.29123. Elife. 2017. PMID: 29256861 Free PMC article.

7

A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach.

Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajić A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY. Rousseaux MWC, et al. J Neurosci. 2018 Oct 24;38(43):9286-9301. doi: 10.1523/JNEUROSCI.0254-18.2018. Epub 2018 Sep 24. J Neurosci. 2018. PMID: 30249792 Free PMC article.

8

Evolutionarily conserved regulators of tau identify targets for new therapies.

Kim J, de Haro M, Al-Ramahi I, Garaicoechea LL, Jeong HH, Sonn JY, Tadros B, Liu Z, Botas J, Zoghbi HY. Kim J, et al. Among authors: al ramahi i. Neuron. 2023 Mar 15;111(6):824-838.e7. doi: 10.1016/j.neuron.2022.12.012. Epub 2023 Jan 6. Neuron. 2023. PMID: 36610398 Free article.

9

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.

Yu M, Ye H, De-Paula RB, Mangleburg CG, Wu T, Lee TV, Li Y, Duong D, Phillips B, Cruchaga C, Allen GI, Seyfried NT, Al-Ramahi I, Botas J, Shulman JM. Yu M, et al. Among authors: al ramahi i. PLoS Genet. 2023 May 18;19(5):e1010760. doi: 10.1371/journal.pgen.1010760. eCollection 2023 May. PLoS Genet. 2023. PMID: 37200393 Free PMC article.

10

Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes.

Li J, Amoh BK, McCormick E, Tarkunde A, Zhu KF, Perez A, Mair M, Moore J, Shulman JM, Al-Ramahi I, Botas J. Li J, et al. Hum Mol Genet. 2023 Jan 27;32(4):685-695. doi: 10.1093/hmg/ddac230. Hum Mol Genet. 2023. PMID: 36173927 Free PMC article.

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