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Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci.
Baronas JM, Bartell E, Eliasen A, Doench JG, Yengo L, Vedantam S, Marouli E; GIANT Consortium; Kronenberg HM, Hirschhorn JN, Renthal NE. Baronas JM, et al. Among authors: doench jg. Cell Genom. 2023 Apr 14;3(5):100299. doi: 10.1016/j.xgen.2023.100299. eCollection 2023 May 10. Cell Genom. 2023. PMID: 37228756 Free PMC article.
HDAC5 controls MEF2C-driven sclerostin expression in osteocytes.
Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM. Wein MN, et al. J Bone Miner Res. 2015 Mar;30(3):400-11. doi: 10.1002/jbmr.2381. J Bone Miner Res. 2015. PMID: 25271055 Free PMC article.
Optimization of Cas12a for multiplexed genome-scale transcriptional activation.
Griffith AL, Zheng F, McGee AV, Miller NW, Szegletes ZM, Reint G, Gademann F, Nwolah I, Hegde M, Liu YV, Goodale A, Doench JG. Griffith AL, et al. Among authors: doench jg. Cell Genom. 2023 Sep 1;3(9):100387. doi: 10.1016/j.xgen.2023.100387. eCollection 2023 Sep 13. Cell Genom. 2023. PMID: 37719144 Free PMC article.
Modular vector assembly enables rapid assessment of emerging CRISPR technologies.
McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Escude Velasco B, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, Green TM, Doench JG. McGee AV, et al. Among authors: doench jg. Cell Genom. 2024 Mar 13;4(3):100519. doi: 10.1016/j.xgen.2024.100519. Cell Genom. 2024. PMID: 38484704 Free PMC article.
Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.
Cacchiarelli D, Trapnell C, Ziller MJ, Soumillon M, Cesana M, Karnik R, Donaghey J, Smith ZD, Ratanasirintrawoot S, Zhang X, Ho Sui SJ, Wu Z, Akopian V, Gifford CA, Doench J, Rinn JL, Daley GQ, Meissner A, Lander ES, Mikkelsen TS. Cacchiarelli D, et al. Cell. 2015 Jul 16;162(2):412-424. doi: 10.1016/j.cell.2015.06.016. Cell. 2015. PMID: 26186193 Free PMC article.
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Wei J, et al. Among authors: doench jg. Cell. 2021 Jan 7;184(1):76-91.e13. doi: 10.1016/j.cell.2020.10.028. Epub 2020 Oct 20. Cell. 2021. PMID: 33147444 Free PMC article.
171 results