Prather PL - Search Results

1

Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats.

Janganati V, Salazar P, Parks BJ, Gorman GS, Prather PL, Peterson EC, Alund AW, Moran JH, Crooks PA, Brents LK. Janganati V, et al. Among authors: prather pl. Front Pharmacol. 2023 May 9;14:1123261. doi: 10.3389/fphar.2023.1123261. eCollection 2023. Front Pharmacol. 2023. PMID: 37229250 Free PMC article.

2

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.

Brents LK, Gallus-Zawada A, Radominska-Pandya A, Vasiljevik T, Prisinzano TE, Fantegrossi WE, Moran JH, Prather PL. Brents LK, et al. Among authors: prather pl. Biochem Pharmacol. 2012 Apr 1;83(7):952-61. doi: 10.1016/j.bcp.2012.01.004. Epub 2012 Jan 18. Biochem Pharmacol. 2012. PMID: 22266354 Free PMC article.

3

Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.

Rajasekaran M, Brents LK, Franks LN, Moran JH, Prather PL. Rajasekaran M, et al. Among authors: prather pl. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):100-8. doi: 10.1016/j.taap.2013.03.012. Epub 2013 Mar 26. Toxicol Appl Pharmacol. 2013. PMID: 23537664 Free PMC article.

4

Differential drug-drug interactions of the synthetic Cannabinoids JWH-018 and JWH-073: implications for drug abuse liability and pain therapy.

Brents LK, Zimmerman SM, Saffell AR, Prather PL, Fantegrossi WE. Brents LK, et al. Among authors: prather pl. J Pharmacol Exp Ther. 2013 Sep;346(3):350-61. doi: 10.1124/jpet.113.206003. Epub 2013 Jun 25. J Pharmacol Exp Ther. 2013. PMID: 23801678 Free PMC article.

5

Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ⁹-THC.

Hutchison RD, Ford BM, Franks LN, Wilson CD, Yarbrough AL, Fujiwara R, Su MK, Fernandez D, James LP, Moran JH, Patton AL, Fantegrossi WE, Radominska-Pandya A, Prather PL. Hutchison RD, et al. Among authors: prather pl. Front Pharmacol. 2018 Sep 26;9:1084. doi: 10.3389/fphar.2018.01084. eCollection 2018. Front Pharmacol. 2018. PMID: 30319418 Free PMC article.

6

Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.

Brents LK, Reichard EE, Zimmerman SM, Moran JH, Fantegrossi WE, Prather PL. Brents LK, et al. Among authors: prather pl. PLoS One. 2011;6(7):e21917. doi: 10.1371/journal.pone.0021917. Epub 2011 Jul 6. PLoS One. 2011. PMID: 21755008 Free PMC article.

7

Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors.

Madadi NR, Penthala NR, Brents LK, Ford BM, Prather PL, Crooks PA. Madadi NR, et al. Among authors: prather pl. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2019-21. doi: 10.1016/j.bmcl.2013.02.025. Epub 2013 Feb 14. Bioorg Med Chem Lett. 2013. PMID: 23466226 Free PMC article.

8

The K2/Spice phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products.

Brents LK, Prather PL. Brents LK, et al. Among authors: prather pl. Drug Metab Rev. 2014 Feb;46(1):72-85. doi: 10.3109/03602532.2013.839700. Epub 2013 Sep 24. Drug Metab Rev. 2014. PMID: 24063277 Free PMC article. Review.

9

Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs.

Franks LN, Ford BM, Madadi NR, Penthala NR, Crooks PA, Prather PL. Franks LN, et al. Among authors: prather pl. Eur J Pharmacol. 2014 Aug 15;737:140-8. doi: 10.1016/j.ejphar.2014.05.007. Epub 2014 May 20. Eur J Pharmacol. 2014. PMID: 24858620 Free PMC article.

10

A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors.

Seely KA, Brents LK, Radominska-Pandya A, Endres GW, Keyes GS, Moran JH, Prather PL. Seely KA, et al. Among authors: prather pl. Chem Res Toxicol. 2012 Apr 16;25(4):825-7. doi: 10.1021/tx3000472. Epub 2012 Mar 15. Chem Res Toxicol. 2012. PMID: 22404317 Free PMC article.

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