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WEE1 inhibitor adavosertib in combination with carboplatin in advanced TP53 mutated ovarian cancer: A biomarker-enriched phase II study.
Embaby A, Kutzera J, Geenen JJ, Pluim D, Hofland I, Sanders J, Lopez-Yurda M, Beijnen JH, Huitema ADR, Witteveen PO, Steeghs N, van Haaften G, van Vugt MATM, de Ridder J, Opdam FL. Embaby A, et al. Among authors: steeghs n. Gynecol Oncol. 2023 Jul;174:239-246. doi: 10.1016/j.ygyno.2023.05.063. Epub 2023 May 24. Gynecol Oncol. 2023. PMID: 37236033 Clinical Trial.
Cisplatin-induced encephalopathy and seizures.
Steeghs N, de Jongh FE, Sillevis Smitt PA, van den Bent MJ. Steeghs N, et al. Anticancer Drugs. 2003 Jul;14(6):443-6. doi: 10.1097/00001813-200307000-00009. Anticancer Drugs. 2003. PMID: 12853886 Review.
Quantification of sunitinib and N-desethyl sunitinib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry: validation and application in routine therapeutic drug monitoring.
Lankheet NA, Steeghs N, Rosing H, Schellens JH, Beijnen JH, Huitema AD. Lankheet NA, et al. Among authors: steeghs n. Ther Drug Monit. 2013 Apr;35(2):168-76. doi: 10.1097/FTD.0b013e31827efd9e. Ther Drug Monit. 2013. PMID: 23503442 Clinical Trial.
Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662.
Diekstra MH, Klümpen HJ, Lolkema MP, Yu H, Kloth JS, Gelderblom H, van Schaik RH, Gurney H, Swen JJ, Huitema AD, Steeghs N, Mathijssen RH. Diekstra MH, et al. Among authors: steeghs n. Clin Pharmacol Ther. 2014 Jul;96(1):81-9. doi: 10.1038/clpt.2014.47. Epub 2014 Feb 24. Clin Pharmacol Ther. 2014. PMID: 24566734
196 results