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The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis.
Davidson JM, Wu SSL, Rayner SL, Cheng F, Duncan K, Russo C, Newbery M, Ding K, Scherer NM, Balez R, García-Redondo A, Rábano A, Rosa-Fernandes L, Ooi L, Williams KL, Morsch M, Blair IP, Di Ieva A, Yang S, Chung RS, Lee A. Davidson JM, et al. Among authors: cheng f. Mol Neurobiol. 2023 Sep;60(9):5034-5054. doi: 10.1007/s12035-023-03355-2. Epub 2023 May 27. Mol Neurobiol. 2023. PMID: 37243816 Free PMC article.
Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD.
Hedl TJ, San Gil R, Cheng F, Rayner SL, Davidson JM, De Luca A, Villalva MD, Ecroyd H, Walker AK, Lee A. Hedl TJ, et al. Among authors: cheng f. Front Neurosci. 2019 Jun 11;13:548. doi: 10.3389/fnins.2019.00548. eCollection 2019. Front Neurosci. 2019. PMID: 31244593 Free PMC article. Review.
ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.
Rayner SL, Cheng F, Hogan AL, Grima N, Yang S, Ke YD, Au CG, Morsch M, De Luca A, Davidson JM, Molloy MP, Shi B, Ittner LM, Blair I, Chung RS, Lee A. Rayner SL, et al. Among authors: cheng f. Hum Mol Genet. 2021 May 31;30(11):971-984. doi: 10.1093/hmg/ddab073. Hum Mol Genet. 2021. PMID: 33729478
Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations.
Cheng F, De Luca A, Hogan AL, Rayner SL, Davidson JM, Watchon M, Stevens CH, Muñoz SS, Ooi L, Yerbury JJ, Don EK, Fifita JA, Villalva MD, Suddull H, Chapman TR, Hedl TJ, Walker AK, Yang S, Morsch M, Shi B, Blair IP, Laird AS, Chung RS, Lee A. Cheng F, et al. Front Mol Neurosci. 2021 Apr 27;14:627740. doi: 10.3389/fnmol.2021.627740. eCollection 2021. Front Mol Neurosci. 2021. PMID: 33986643 Free PMC article.
TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex.
Rayner SL, Yang S, Farrawell NE, Jagaraj CJ, Cheng F, Davidson JM, Luu L, Redondo AG, Rábano A, Borrego-Hernández D, Atkin JD, Morsch M, Blair IP, Yerbury JJ, Chung R, Lee A. Rayner SL, et al. Among authors: cheng f. Neurobiol Dis. 2022 Jun 1;167:105673. doi: 10.1016/j.nbd.2022.105673. Epub 2022 Feb 26. Neurobiol Dis. 2022. PMID: 35231559 Free article.
Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD.
Rayner SL, Hogan A, Davidson JM, Cheng F, Luu L, Morsch M, Blair I, Chung R, Lee A. Rayner SL, et al. Among authors: cheng f. Neuroscientist. 2024 Apr;30(2):214-228. doi: 10.1177/10738584221120182. Epub 2022 Sep 5. Neuroscientist. 2024. PMID: 36062310 Review.
Identification of phosphorylated tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission.
Radford RAW, Rayner SL, Szwaja P, Morsch M, Cheng F, Zhu T, Widagdo J, Anggono V, Pountney DL, Chung R, Lee A. Radford RAW, et al. Among authors: cheng f. J Neurochem. 2023 May;165(4):563-586. doi: 10.1111/jnc.15796. Epub 2023 Mar 21. J Neurochem. 2023. PMID: 36847488 Free PMC article.
4,406 results