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Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis.
Blood. 2023 Aug 31;142(9):827-845. doi: 10.1182/blood.2022018303.
Blood. 2023.
PMID: 37249233
Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation.
Shalaby R, Diwan A, Flores-Romero H, Hertlein V, Garcia-Saez AJ.
Shalaby R, et al. Among authors: hertlein v.
Cell Death Differ. 2023 Mar;30(3):731-741. doi: 10.1038/s41418-022-01078-w. Epub 2022 Oct 26.
Cell Death Differ. 2023.
PMID: 36289446
Free PMC article.
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The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation.
Cosentino K, Hertlein V, Jenner A, Dellmann T, Gojkovic M, Peña-Blanco A, Dadsena S, Wajngarten N, Danial JSH, Thevathasan JV, Mund M, Ries J, Garcia-Saez AJ.
Cosentino K, et al. Among authors: hertlein v.
Mol Cell. 2022 Mar 3;82(5):933-949.e9. doi: 10.1016/j.molcel.2022.01.008. Epub 2022 Feb 3.
Mol Cell. 2022.
PMID: 35120587
Free PMC article.
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BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.
Flores-Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L, Szabo T, Hertlein V, Luo X, Villunger A, Frenzel LP, Kashkar H, Garcia-Saez AJ.
Flores-Romero H, et al. Among authors: hertlein v.
EMBO J. 2022 Dec 17;41(2):e108690. doi: 10.15252/embj.2021108690. Epub 2021 Dec 21.
EMBO J. 2022.
PMID: 34931711
Free PMC article.
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MERLIN: a novel BRET-based proximity biosensor for studying mitochondria-ER contact sites.
Hertlein V, Flores-Romero H, Das KK, Fischer S, Heunemann M, Calleja-Felipe M, Knafo S, Hipp K, Harter K, Fitzgerald JC, García-Sáez AJ.
Hertlein V, et al.
Life Sci Alliance. 2019 Dec 9;3(1):e201900600. doi: 10.26508/lsa.201900600. Print 2020 Jan.
Life Sci Alliance. 2019.
PMID: 31818884
Free PMC article.
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