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Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.
Packer RJ, Shrine N, Hall R, Melbourne CA, Thompson R, Williams AT, Paynton ML, Guyatt AL, Allen RJ, Lee PH, John C, Campbell A, Hayward C, de Vries M, Vonk JM, Davitte J, Hessel E, Michalovich D, Betts JC, Sayers I, Yeo A, Hall IP, Tobin MD, Wain LV. Packer RJ, et al. Among authors: hessel e. Eur Respir J. 2023 Jun 15;61(6):2201667. doi: 10.1183/13993003.01667-2022. Print 2023 Jun. Eur Respir J. 2023. PMID: 37263751 Free PMC article.
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.
Rapiteanu R, Karagyozova T, Zimmermann N, Singh K, Wayne G, Martufi M, Belyaev NN, Hessel EM, Michalovich D, Macarron R, Rowan WC, Cairns WJ, Roger J, Betts J, Beinke S, Maratou K. Rapiteanu R, et al. Eur Respir J. 2020 May 21;55(5):1900950. doi: 10.1183/13993003.00950-2019. Print 2020 May. Eur Respir J. 2020. PMID: 32060058 Free article. No abstract available.
Histamine-secreting microbes are increased in the gut of adult asthma patients.
Barcik W, Pugin B, Westermann P, Perez NR, Ferstl R, Wawrzyniak M, Smolinska S, Jutel M, Hessel EM, Michalovich D, Akdis CA, Frei R, O'Mahony L. Barcik W, et al. J Allergy Clin Immunol. 2016 Nov;138(5):1491-1494.e7. doi: 10.1016/j.jaci.2016.05.049. Epub 2016 Jul 27. J Allergy Clin Immunol. 2016. PMID: 27576125 No abstract available.
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.
Michalovich D, Rodriguez-Perez N, Smolinska S, Pirozynski M, Mayhew D, Uddin S, Van Horn S, Sokolowska M, Altunbulakli C, Eljaszewicz A, Pugin B, Barcik W, Kurnik-Lucka M, Saunders KA, Simpson KD, Schmid-Grendelmeier P, Ferstl R, Frei R, Sievi N, Kohler M, Gajdanowicz P, Graversen KB, Lindholm Bøgh K, Jutel M, Brown JR, Akdis CA, Hessel EM, O'Mahony L. Michalovich D, et al. Nat Commun. 2019 Dec 13;10(1):5711. doi: 10.1038/s41467-019-13751-9. Nat Commun. 2019. PMID: 31836714 Free PMC article.
Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection.
Groeger D, Schiavi E, Grant R, Kurnik-Łucka M, Michalovich D, Williamson R, Beinke S, Kiely B, Akdis CA, Hessel EM, Shanahan F, O' Mahony L. Groeger D, et al. Among authors: hessel em. EBioMedicine. 2020 Oct;60:102981. doi: 10.1016/j.ebiom.2020.102981. Epub 2020 Sep 11. EBioMedicine. 2020. PMID: 32927273 Free PMC article.
Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma.
Rodriguez-Perez N, Schiavi E, Frei R, Ferstl R, Wawrzyniak P, Smolinska S, Sokolowska M, Sievi NA, Kohler M, Schmid-Grendelmeier P, Michalovich D, Simpson KD, Hessel EM, Jutel M, Martin-Fontecha M, Palomares O, Akdis CA, O'Mahony L. Rodriguez-Perez N, et al. Among authors: hessel em. Allergy. 2017 Nov;72(11):1744-1752. doi: 10.1111/all.13180. Epub 2017 May 10. Allergy. 2017. PMID: 28397284 Free article.
Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials.
Begg M, Hamblin JN, Jarvis E, Bradley G, Mark S, Michalovich D, Lennon M, Wajdner HE, Amour A, Wilson R, Saunders K, Tanaka R, Arai S, Tang T, Van Holsbeke C, De Backer J, Vos W, Titlestad IL, FitzGerald JM, Killian K, Bourbeau J, Poirier C, Maltais F, Cahn A, Hessel EM. Begg M, et al. Among authors: hessel em. Int J Chron Obstruct Pulmon Dis. 2021 Jun 3;16:1621-1636. doi: 10.2147/COPD.S309303. eCollection 2021. Int J Chron Obstruct Pulmon Dis. 2021. PMID: 34113094 Free PMC article.
Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.
Wronski S, Beinke S, Obernolte H, Belyaev NN, Saunders KA, Lennon MG, Schaudien D, Braubach P, Jonigk D, Warnecke G, Zardo P, Fieguth HG, Wilkens L, Braun A, Hessel EM, Sewald K. Wronski S, et al. Am J Respir Cell Mol Biol. 2021 Nov;65(5):544-554. doi: 10.1165/rcmb.2020-0337OC. Am J Respir Cell Mol Biol. 2021. PMID: 34181859 Free PMC article.
238 results