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Page 1
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity.
Arora M, Moser J, Hoffman TE, Watts LP, Min M, Musteanu M, Rong Y, Ill CR, Nangia V, Schneider J, Sanclemente M, Lapek J, Nguyen L, Niessen S, Dann S, VanArsdale T, Barbacid M, Miller N, Spencer SL. Arora M, et al. Among authors: vanarsdale t. Cell. 2023 Jun 8;186(12):2628-2643.e21. doi: 10.1016/j.cell.2023.05.013. Epub 2023 Jun 1. Cell. 2023. PMID: 37267950
Expanding the ligandable proteome by paralog hopping with covalent probes.
Zhang Y, Liu Z, Hirschi M, Brodsky O, Johnson E, Won SJ, Nagata A, Petroski MD, Majmudar JD, Niessen S, VanArsdale T, Gilbert AM, Hayward MM, Stewart AE, Nager AR, Melillo B, Cravatt B. Zhang Y, et al. Among authors: vanarsdale t. bioRxiv [Preprint]. 2024 Jan 19:2024.01.18.576274. doi: 10.1101/2024.01.18.576274. bioRxiv. 2024. PMID: 38293178 Free PMC article. Preprint.
Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation.
Ford K, Munson BP, Fong SH, Panwala R, Chu WK, Rainaldi J, Plongthongkum N, Arunachalam V, Kostrowicki J, Meluzzi D, Kreisberg JF, Jensen-Pergakes K, VanArsdale T, Paul T, Tamayo P, Zhang K, Bienkowska J, Mali P, Ideker T. Ford K, et al. Among authors: vanarsdale t. Sci Rep. 2023 May 11;13(1):7678. doi: 10.1038/s41598-023-33329-2. Sci Rep. 2023. PMID: 37169829 Free PMC article.
A two-step mechanism governing PARP1-DNA retention by PARP inhibitors.
Xue H, Bhardwaj A, Yin Y, Fijen C, Ephstein A, Zhang L, Ding X, Pascal JM, VanArsdale TL, Rothenberg E. Xue H, et al. Among authors: vanarsdale tl. Sci Adv. 2022 Sep 9;8(36):eabq0414. doi: 10.1126/sciadv.abq0414. Epub 2022 Sep 7. Sci Adv. 2022. PMID: 36070389 Free PMC article.
Comparative biomarker analysis of PALOMA-2/3 trials for palbociclib.
Zhu Z, Turner NC, Loi S, André F, Martin M, Diéras V, Gelmon KA, Harbeck N, Zhang C, Cao JQ, Yan Z, Lu DR, Wei P, VanArsdale TL, Rejto PA, Huang X, Rugo HS, Loibl S, Cristofanilli M, Finn RS, Liu Y. Zhu Z, et al. Among authors: vanarsdale tl. NPJ Precis Oncol. 2022 Aug 16;6(1):56. doi: 10.1038/s41698-022-00297-1. NPJ Precis Oncol. 2022. PMID: 35974168 Free PMC article.
PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib.
Ding X, Zhu Z, Lapek J, McMillan EA, Zhang A, Chung CY, Dubbury S, Lapira J, Firdaus S, Kang X, Gao J, Oyer J, Chionis J, Rollins RA, Li L, Niessen S, Bagrodia S, Zhang L, VanArsdale T. Ding X, et al. Among authors: vanarsdale t. Sci Rep. 2022 Jul 21;12(1):12501. doi: 10.1038/s41598-022-16623-3. Sci Rep. 2022. PMID: 35864202 Free PMC article.
Real-World Data of Palbociclib in Combination With Endocrine Therapy for the Treatment of Metastatic Breast Cancer in Men.
Kraus AL, Yu-Kite M, Mardekian J, Cotter MJ, Kim S, Decembrino J, Snow T, Carson KR, Motyl Rockland J, Gossai A, Wilner K, Wang DD, Huang Bartlett C, Oharu N, Schnell P, VanArsdale T, Lu DR, Tursi JM. Kraus AL, et al. Among authors: vanarsdale t. Clin Pharmacol Ther. 2022 Jan;111(1):302-309. doi: 10.1002/cpt.2454. Epub 2021 Nov 19. Clin Pharmacol Ther. 2022. PMID: 34668577
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.
Freeman-Cook K, Hoffman RL, Miller N, Almaden J, Chionis J, Zhang Q, Eisele K, Liu C, Zhang C, Huser N, Nguyen L, Costa-Jones C, Niessen S, Carelli J, Lapek J, Weinrich SL, Wei P, McMillan E, Wilson E, Wang TS, McTigue M, Ferre RA, He YA, Ninkovic S, Behenna D, Tran KT, Sutton S, Nagata A, Ornelas MA, Kephart SE, Zehnder LR, Murray B, Xu M, Solowiej JE, Visswanathan R, Boras B, Looper D, Lee N, Bienkowska JR, Zhu Z, Kan Z, Ding Y, Mu XJ, Oderup C, Salek-Ardakani S, White MA, VanArsdale T, Dann SG. Freeman-Cook K, et al. Among authors: vanarsdale t. Cancer Cell. 2021 Oct 11;39(10):1404-1421.e11. doi: 10.1016/j.ccell.2021.08.009. Epub 2021 Sep 13. Cancer Cell. 2021. PMID: 34520734 Free article.
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
Ryan K, Bolaňos B, Smith M, Palde PB, Cuenca PD, VanArsdale TL, Niessen S, Zhang L, Behenna D, Ornelas MA, Tran KT, Kaiser S, Lum L, Stewart A, Gajiwala KS. Ryan K, et al. Among authors: vanarsdale tl. J Biol Chem. 2021 Jan-Jun;296:100251. doi: 10.1074/jbc.RA120.016573. Epub 2021 Jan 9. J Biol Chem. 2021. PMID: 33361107 Free PMC article.
CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma.
Salvador-Barbero B, Alvarez-Fernández M, Zapatero-Solana E, El Bakkali A, Menéndez MDC, López-Casas PP, Di Domenico T, Xie T, VanArsdale T, Shields DJ, Hidalgo M, Malumbres M. Salvador-Barbero B, et al. Among authors: vanarsdale t. Cancer Cell. 2020 Oct 12;38(4):584. doi: 10.1016/j.ccell.2020.09.012. Cancer Cell. 2020. PMID: 33049208 Free article. No abstract available.
41 results