Vendruscolo M - Search Results

1

Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation.

Vendruscolo M. Vendruscolo M. Expert Opin Drug Discov. 2023 Jul-Dec;18(8):881-891. doi: 10.1080/17460441.2023.2221024. Epub 2023 Jun 5. Expert Opin Drug Discov. 2023. PMID: 37276120 Review.

2

SAR by kinetics for drug discovery in protein misfolding diseases.

Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. Chia S, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10245-10250. doi: 10.1073/pnas.1807884115. Epub 2018 Sep 26. Proc Natl Acad Sci U S A. 2018. PMID: 30257937 Free PMC article.

3

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases.

Sinnige T, Stroobants K, Dobson CM, Vendruscolo M. Sinnige T, et al. Among authors: vendruscolo m. Q Rev Biophys. 2020 Jun 4;49:e22. doi: 10.1017/S0033583520000025. Q Rev Biophys. 2020. PMID: 32493529

4

Pharmacological inhibition of α-synuclein aggregation within liquid condensates.

Dada ST, Toprakcioglu Z, Cali MP, Röntgen A, Hardenberg MC, Morris OM, Mrugalla LK, Knowles TPJ, Vendruscolo M. Dada ST, et al. Among authors: vendruscolo m. Nat Commun. 2024 May 7;15(1):3835. doi: 10.1038/s41467-024-47585-x. Nat Commun. 2024. PMID: 38714700 Free PMC article.

5

Theoretical approaches to protein aggregation.

Gsponer J, Vendruscolo M. Gsponer J, et al. Among authors: vendruscolo m. Protein Pept Lett. 2006;13(3):287-93. doi: 10.2174/092986606775338407. Protein Pept Lett. 2006. PMID: 16515457 Review.

6

Chemical kinetics for drug discovery to combat protein aggregation diseases.

Arosio P, Vendruscolo M, Dobson CM, Knowles TP. Arosio P, et al. Among authors: vendruscolo m. Trends Pharmacol Sci. 2014 Mar;35(3):127-35. doi: 10.1016/j.tips.2013.12.005. Epub 2014 Feb 20. Trends Pharmacol Sci. 2014. PMID: 24560688 Review.

7

The amyloid state and its association with protein misfolding diseases.

Knowles TP, Vendruscolo M, Dobson CM. Knowles TP, et al. Among authors: vendruscolo m. Nat Rev Mol Cell Biol. 2014 Jun;15(6):384-96. doi: 10.1038/nrm3810. Nat Rev Mol Cell Biol. 2014. PMID: 24854788 Review.

8

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

Meisl G, Kirkegaard JB, Arosio P, Michaels TC, Vendruscolo M, Dobson CM, Linse S, Knowles TP. Meisl G, et al. Among authors: vendruscolo m. Nat Protoc. 2016 Feb;11(2):252-72. doi: 10.1038/nprot.2016.010. Epub 2016 Jan 7. Nat Protoc. 2016. PMID: 26741409

9

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S. Cohen SIA, et al. Among authors: vendruscolo m. Nat Chem. 2018 May;10(5):523-531. doi: 10.1038/s41557-018-0023-x. Epub 2018 Mar 26. Nat Chem. 2018. PMID: 29581486 Free PMC article.

10

Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.

Delivoria DC, Chia S, Habchi J, Perni M, Matis I, Papaevgeniou N, Reczko M, Chondrogianni N, Dobson CM, Vendruscolo M, Skretas G. Delivoria DC, et al. Among authors: vendruscolo m. Sci Adv. 2019 Oct 16;5(10):eaax5108. doi: 10.1126/sciadv.aax5108. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31663025 Free PMC article.

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