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OECD harmonised template 201: Structuring and reporting mechanistic information to foster the integration of new approach methodologies for hazard and risk assessment of chemicals.
Carnesecchi E, Langezaal I, Browne P, Batista-Leite S, Campia I, Coecke S, Dagallier B, Deceuninck P, Dorne JLC, Tarazona JV, Le Goff F, Leinala E, Morath S, Munn S, Richardson J, Paini A, Wittwehr C. Carnesecchi E, et al. Among authors: paini a. Regul Toxicol Pharmacol. 2023 Aug;142:105426. doi: 10.1016/j.yrtph.2023.105426. Epub 2023 Jun 3. Regul Toxicol Pharmacol. 2023. PMID: 37277057 Review.
How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology.
Wittwehr C, Aladjov H, Ankley G, Byrne HJ, de Knecht J, Heinzle E, Klambauer G, Landesmann B, Luijten M, MacKay C, Maxwell G, Meek ME, Paini A, Perkins E, Sobanski T, Villeneuve D, Waters KM, Whelan M. Wittwehr C, et al. Among authors: paini a. Toxicol Sci. 2017 Feb;155(2):326-336. doi: 10.1093/toxsci/kfw207. Epub 2016 Dec 19. Toxicol Sci. 2017. PMID: 27994170 Free PMC article.
Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum.
Laroche C, Aggarwal M, Bender H, Benndorf P, Birk B, Crozier J, Dal Negro G, De Gaetano F, Desaintes C, Gardner I, Hubesch B, Irizar A, John D, Kumar V, Lostia A, Manou I, Monshouwer M, Müller BP, Paini A, Reid K, Rowan T, Sachana M, Schutte K, Stirling C, Taalman R, van Aerts L, Weissenhorn R, Sauer UG. Laroche C, et al. Among authors: paini a. Regul Toxicol Pharmacol. 2018 Nov;99:5-21. doi: 10.1016/j.yrtph.2018.08.006. Epub 2018 Aug 23. Regul Toxicol Pharmacol. 2018. PMID: 30144470 Free article.
PBPK model reporting template for chemical risk assessment applications.
Tan YM, Chan M, Chukwudebe A, Domoradzki J, Fisher J, Hack CE, Hinderliter P, Hirasawa K, Leonard J, Lumen A, Paini A, Qian H, Ruiz P, Wambaugh J, Zhang F, Embry M. Tan YM, et al. Among authors: paini a. Regul Toxicol Pharmacol. 2020 Aug;115:104691. doi: 10.1016/j.yrtph.2020.104691. Epub 2020 Jun 2. Regul Toxicol Pharmacol. 2020. PMID: 32502513 Free PMC article. Review.
New approach methodologies (NAMs) for human-relevant biokinetics predictions. Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.
Punt A, Bouwmeester H, Blaauboer BJ, Coecke S, Hakkert B, Hendriks DFG, Jennings P, Kramer NI, Neuhoff S, Masereeuw R, Paini A, Peijnenburg AACM, Rooseboom M, Shuler ML, Sorrell I, Spee B, Strikwold M, Van der Meer AD, Van der Zande M, Vinken M, Yang H, Bos PMJ, Heringa MB. Punt A, et al. Among authors: paini a. ALTEX. 2020;37(4):607-622. doi: 10.14573/altex.2003242. Epub 2020 Jun 8. ALTEX. 2020. PMID: 32521035 Free article.
Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies.
Pistollato F, Madia F, Corvi R, Munn S, Grignard E, Paini A, Worth A, Bal-Price A, Prieto P, Casati S, Berggren E, Bopp SK, Zuang V. Pistollato F, et al. Among authors: paini a. Arch Toxicol. 2021 Jun;95(6):1867-1897. doi: 10.1007/s00204-021-03034-y. Epub 2021 Apr 13. Arch Toxicol. 2021. PMID: 33851225 Free PMC article. Review.
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine.
Bury D, Alexander-White C, Clewell HJ 3rd, Cronin M, Desprez B, Detroyer A, Efremenko A, Firman J, Hack E, Hewitt NJ, Kenna G, Klaric M, Lester C, Mahony C, Ouedraogo G, Paini A, Schepky A; Cosmetics Europe. Bury D, et al. Among authors: paini a. Regul Toxicol Pharmacol. 2021 Jul;123:104931. doi: 10.1016/j.yrtph.2021.104931. Epub 2021 Apr 24. Regul Toxicol Pharmacol. 2021. PMID: 33905778 Free article.
Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment.
Tan YM, Barton HA, Boobis A, Brunner R, Clewell H, Cope R, Dawson J, Domoradzki J, Egeghy P, Gulati P, Ingle B, Kleinstreuer N, Lowe K, Lowit A, Mendez E, Miller D, Minucci J, Nguyen J, Paini A, Perron M, Phillips K, Qian H, Ramanarayanan T, Sewell F, Villanueva P, Wambaugh J, Embry M. Tan YM, et al. Among authors: paini a. Regul Toxicol Pharmacol. 2021 Dec;127:105070. doi: 10.1016/j.yrtph.2021.105070. Epub 2021 Oct 28. Regul Toxicol Pharmacol. 2021. PMID: 34718074 Free PMC article.
177 results