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Epigenetic dysregulation from chromosomal transit in micronuclei.
Agustinus AS, Al-Rawi D, Dameracharla B, Raviram R, Jones BSCL, Stransky S, Scipioni L, Luebeck J, Di Bona M, Norkunaite D, Myers RM, Duran M, Choi S, Weigelt B, Yomtoubian S, McPherson A, Toufektchan E, Keuper K, Mischel PS, Mittal V, Shah SP, Maciejowski J, Storchova Z, Gratton E, Ly P, Landau D, Bakhoum MF, Koche RP, Sidoli S, Bafna V, David Y, Bakhoum SF. Agustinus AS, et al. Among authors: koche rp. Nature. 2023 Jul;619(7968):176-183. doi: 10.1038/s41586-023-06084-7. Epub 2023 Jun 7. Nature. 2023. PMID: 37286593 Free PMC article.
GC-rich sequence elements recruit PRC2 in mammalian ES cells.
Mendenhall EM, Koche RP, Truong T, Zhou VW, Issac B, Chi AS, Ku M, Bernstein BE. Mendenhall EM, et al. Among authors: koche rp. PLoS Genet. 2010 Dec 9;6(12):e1001244. doi: 10.1371/journal.pgen.1001244. PLoS Genet. 2010. PMID: 21170310 Free PMC article.
Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.
Kleppe M, Koche R, Zou L, van Galen P, Hill CE, Dong L, De Groote S, Papalexi E, Hanasoge Somasundara AV, Cordner K, Keller M, Farnoud N, Medina J, McGovern E, Reyes J, Roberts J, Witkin M, Rapaport F, Teruya-Feldstein J, Qi J, Rampal R, Bernstein BE, Bradner JE, Levine RL. Kleppe M, et al. Cancer Cell. 2018 Apr 9;33(4):785-787. doi: 10.1016/j.ccell.2018.03.024. Cancer Cell. 2018. PMID: 29634952 Free PMC article. No abstract available.
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Sun Y, Zhou B, Mao F, Xu J, Miao H, Zou Z, Phuc Khoa LT, Jang Y, Cai S, Witkin M, Koche R, Ge K, Dressler GR, Levine RL, Armstrong SA, Dou Y, Hess JL. Sun Y, et al. Cancer Cell. 2018 Oct 8;34(4):643-658.e5. doi: 10.1016/j.ccell.2018.08.018. Epub 2018 Sep 27. Cancer Cell. 2018. PMID: 30270123 Free PMC article.
The MicrobesOnline Web site for comparative genomics.
Alm EJ, Huang KH, Price MN, Koche RP, Keller K, Dubchak IL, Arkin AP. Alm EJ, et al. Among authors: koche rp. Genome Res. 2005 Jul;15(7):1015-22. doi: 10.1101/gr.3844805. Genome Res. 2005. PMID: 15998914 Free PMC article.
Mutant FOXL2C134W Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors.
Weis-Banke SE, Lerdrup M, Kleine-Kohlbrecher D, Mohammad F, Sidoli S, Jensen ON, Yanase T, Nakamura T, Iwase A, Stylianou A, Abu-Rustum NR, Aghajanian C, Soslow R, Da Cruz Paula A, Koche RP, Weigelt B, Christensen J, Helin K, Cloos PAC. Weis-Banke SE, et al. Among authors: koche rp. Cancer Res. 2020 Sep 1;80(17):3466-3479. doi: 10.1158/0008-5472.CAN-20-0259. Epub 2020 Jul 8. Cancer Res. 2020. PMID: 32641411 Free PMC article.
A gene-environment-induced epigenetic program initiates tumorigenesis.
Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe'er D, Lowe SW. Alonso-Curbelo D, et al. Nature. 2021 Feb;590(7847):642-648. doi: 10.1038/s41586-020-03147-x. Epub 2021 Feb 3. Nature. 2021. PMID: 33536616 Free PMC article.
107 results