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Class B1 GPCR activation by an intracellular agonist.
Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O. Kobayashi K, et al. Among authors: taguchi t. Nature. 2023 Jun;618(7967):1085-1093. doi: 10.1038/s41586-023-06169-3. Epub 2023 Jun 7. Nature. 2023. PMID: 37286611 Free PMC article.
Homeostatic regulation of STING by retrograde membrane traffic to the ER.
Mukai K, Ogawa E, Uematsu R, Kuchitsu Y, Kiku F, Uemura T, Waguri S, Suzuki T, Dohmae N, Arai H, Shum AK, Taguchi T. Mukai K, et al. Among authors: taguchi t. Nat Commun. 2021 Jan 4;12(1):61. doi: 10.1038/s41467-020-20234-9. Nat Commun. 2021. PMID: 33397928 Free PMC article.
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes.
Kuchitsu Y, Mukai K, Uematsu R, Takaada Y, Shinojima A, Shindo R, Shoji T, Hamano S, Ogawa E, Sato R, Miyake K, Kato A, Kawaguchi Y, Nishitani-Isa M, Izawa K, Nishikomori R, Yasumi T, Suzuki T, Dohmae N, Uemura T, Barber GN, Arai H, Waguri S, Taguchi T. Kuchitsu Y, et al. Among authors: taguchi t. Nat Cell Biol. 2023 Mar;25(3):453-466. doi: 10.1038/s41556-023-01098-9. Epub 2023 Mar 13. Nat Cell Biol. 2023. PMID: 36918692 Free PMC article.
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol.
Kemmoku H, Takahashi K, Mukai K, Mori T, Hirosawa KM, Kiku F, Uchida Y, Kuchitsu Y, Nishioka Y, Sawa M, Kishimoto T, Tanaka K, Yokota Y, Arai H, Suzuki KGN, Taguchi T. Kemmoku H, et al. Among authors: taguchi t. Nat Commun. 2024 Jan 11;15(1):220. doi: 10.1038/s41467-023-44317-5. Nat Commun. 2024. PMID: 38212328 Free PMC article.
Activation of STING requires palmitoylation at the Golgi.
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, Barber GN, Arai H, Taguchi T. Mukai K, et al. Among authors: taguchi t. Nat Commun. 2016 Jun 21;7:11932. doi: 10.1038/ncomms11932. Nat Commun. 2016. PMID: 27324217 Free PMC article.
A non-nucleotide agonist that binds covalently to cysteine residues of STING.
Matsumoto K, Ni S, Arai H, Toyama T, Saito Y, Suzuki T, Dohmae N, Mukai K, Taguchi T. Matsumoto K, et al. Among authors: taguchi t. Cell Struct Funct. 2023 Feb 16;48(1):59-70. doi: 10.1247/csf.22085. Epub 2022 Dec 28. Cell Struct Funct. 2023. PMID: 36575042 Free PMC article.
Mentoring the next generation of cell biologists.
Applewhite DA, Bhalla N, Cabezas-Wallscheid N, Erez N, Li M, Polo JM, Taguchi T, Thiam AR, Wang X. Applewhite DA, et al. Among authors: taguchi t. Nat Cell Biol. 2024 Jan;26(1):15-18. doi: 10.1038/s41556-023-01278-7. Nat Cell Biol. 2024. PMID: 38228826 No abstract available.
2,935 results