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An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.
Sheehan PW, Nadarajah CJ, Kanan MF, Patterson JN, Novotny B, Lawrence JH, King MW, Brase L, Inman CE, Yuede CM, Lee J, Patel TK, Harari O, Benitez BA, Davis AA, Musiek ES. Sheehan PW, et al. Among authors: patel tk. Neuron. 2023 Aug 2;111(15):2383-2398.e7. doi: 10.1016/j.neuron.2023.05.006. Epub 2023 Jun 13. Neuron. 2023. PMID: 37315555
Dural lymphatics regulate clearance of extracellular tau from the CNS.
Patel TK, Habimana-Griffin L, Gao X, Xu B, Achilefu S, Alitalo K, McKee CA, Sheehan PW, Musiek ES, Xiong C, Coble D, Holtzman DM. Patel TK, et al. Mol Neurodegener. 2019 Feb 27;14(1):11. doi: 10.1186/s13024-019-0312-x. Mol Neurodegener. 2019. PMID: 30813965 Free PMC article.
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy.
Yanamandra K, Patel TK, Jiang H, Schindler S, Ulrich JD, Boxer AL, Miller BL, Kerwin DR, Gallardo G, Stewart F, Finn MB, Cairns NJ, Verghese PB, Fogelman I, West T, Braunstein J, Robinson G, Keyser J, Roh J, Knapik SS, Hu Y, Holtzman DM. Yanamandra K, et al. Among authors: patel tk. Sci Transl Med. 2017 Apr 19;9(386):eaal2029. doi: 10.1126/scitranslmed.aal2029. Sci Transl Med. 2017. PMID: 28424326 Free PMC article.
Sleep in Alzheimer's Disease - Beyond Amyloid.
Holth J, Patel T, Holtzman DM. Holth J, et al. Neurobiol Sleep Circadian Rhythms. 2017 Jan;2:4-14. doi: 10.1016/j.nbscr.2016.08.002. Epub 2016 Aug 10. Neurobiol Sleep Circadian Rhythms. 2017. PMID: 28217760 Free PMC article.
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Yamada K, Patel TK, Hochgräfe K, Mahan TE, Jiang H, Stewart FR, Mandelkow EM, Holtzman DM. Yamada K, et al. Among authors: patel tk. Mol Neurodegener. 2015 Oct 26;10:55. doi: 10.1186/s13024-015-0052-5. Mol Neurodegener. 2015. PMID: 26502977 Free PMC article.
Neuronal activity regulates extracellular tau in vivo.
Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, Cirrito JR, Patel TK, Hochgräfe K, Mandelkow EM, Holtzman DM. Yamada K, et al. Among authors: patel tk. J Exp Med. 2014 Mar 10;211(3):387-93. doi: 10.1084/jem.20131685. Epub 2014 Feb 17. J Exp Med. 2014. PMID: 24534188 Free PMC article.
97 results