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Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A.
Koga H, Yamano T, Betancur J, Nagatomo S, Ikeda Y, Yamaguchi K, Nabuchi Y, Sato K, Teranishi-Ikawa Y, Sato M, Hirayama H, Hayasaka A, Torizawa T, Haraya K, Sampei Z, Shiraiwa H, Kitazawa T, Igawa T, Kuramochi T. Koga H, et al. Among authors: nabuchi y. MAbs. 2023 Jan-Dec;15(1):2222441. doi: 10.1080/19420862.2023.2222441. MAbs. 2023. PMID: 37339067 Free PMC article.
Reduced elimination of IgG antibodies by engineering the variable region.
Igawa T, Tsunoda H, Tachibana T, Maeda A, Mimoto F, Moriyama C, Nanami M, Sekimori Y, Nabuchi Y, Aso Y, Hattori K. Igawa T, et al. Among authors: nabuchi y. Protein Eng Des Sel. 2010 May;23(5):385-92. doi: 10.1093/protein/gzq009. Epub 2010 Feb 15. Protein Eng Des Sel. 2010. PMID: 20159773
Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization.
Igawa T, Ishii S, Tachibana T, Maeda A, Higuchi Y, Shimaoka S, Moriyama C, Watanabe T, Takubo R, Doi Y, Wakabayashi T, Hayasaka A, Kadono S, Miyazaki T, Haraya K, Sekimori Y, Kojima T, Nabuchi Y, Aso Y, Kawabe Y, Hattori K. Igawa T, et al. Among authors: nabuchi y. Nat Biotechnol. 2010 Nov;28(11):1203-7. doi: 10.1038/nbt.1691. Epub 2010 Oct 17. Nat Biotechnol. 2010. PMID: 20953198
Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity.
Sampei Z, Igawa T, Soeda T, Okuyama-Nishida Y, Moriyama C, Wakabayashi T, Tanaka E, Muto A, Kojima T, Kitazawa T, Yoshihashi K, Harada A, Funaki M, Haraya K, Tachibana T, Suzuki S, Esaki K, Nabuchi Y, Hattori K. Sampei Z, et al. Among authors: nabuchi y. PLoS One. 2013;8(2):e57479. doi: 10.1371/journal.pone.0057479. Epub 2013 Feb 28. PLoS One. 2013. PMID: 23468998 Free PMC article.
30 results