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Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis.
Medina-Gomez C, Mullin BH, Chesi A, Prijatelj V, Kemp JP, Shochat-Carvalho C, Trajanoska K, Wang C, Joro R, Evans TE, Schraut KE, Li-Gao R, Ahluwalia TS, Zillikens MC, Zhu K, Mook-Kanamori DO, Evans DS, Nethander M, Knol MJ, Thorleifsson G, Prokic I, Zemel B, Broer L, McGuigan FE, van Schoor NM, Reppe S, Pawlak MA, Ralston SH, van der Velde N, Lorentzon M, Stefansson K, Adams HHH, Wilson SG, Ikram MA, Walsh JP, Lakka TA, Gautvik KM, Wilson JF, Orwoll ES, van Duijn CM, Bønnelykke K, Uitterlinden AG, Styrkársdóttir U, Akesson KE, Spector TD, Tobias JH, Ohlsson C, Felix JF, Bisgaard H, Grant SFA, Richards JB, Evans DM, van der Eerden B, van de Peppel J, Ackert-Bicknell C, Karasik D, Kague E, Rivadeneira F. Medina-Gomez C, et al. Among authors: orwoll es. Commun Biol. 2023 Jul 4;6(1):691. doi: 10.1038/s42003-023-04869-0. Commun Biol. 2023. PMID: 37402774 Free PMC article.
SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density.
Eriksson AL, Lorentzon M, Mellström D, Vandenput L, Swanson C, Andersson N, Hammond GL, Jakobsson J, Rane A, Orwoll ES, Ljunggren O, Johnell O, Labrie F, Windahl SH, Ohlsson C. Eriksson AL, et al. Among authors: orwoll es. J Clin Endocrinol Metab. 2006 Dec;91(12):5029-37. doi: 10.1210/jc.2006-0679. Epub 2006 Aug 22. J Clin Endocrinol Metab. 2006. PMID: 16926255
The impact of estradiol on bone mineral density is modulated by the specific estrogen receptor-alpha cofactor retinoblastoma-interacting zinc finger protein-1 insertion/deletion polymorphism.
Grundberg E, Akesson K, Kindmark A, Gerdhem P, Holmberg A, Mellström D, Ljunggren O, Orwoll E, Mallmin H, Ohlsson C, Brändström H. Grundberg E, et al. J Clin Endocrinol Metab. 2007 Jun;92(6):2300-6. doi: 10.1210/jc.2006-1572. Epub 2007 Mar 13. J Clin Endocrinol Metab. 2007. PMID: 17356055
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.
van Meurs JB, Trikalinos TA, Ralston SH, Balcells S, Brandi ML, Brixen K, Kiel DP, Langdahl BL, Lips P, Ljunggren O, Lorenc R, Obermayer-Pietsch B, Ohlsson C, Pettersson U, Reid DM, Rousseau F, Scollen S, Van Hul W, Agueda L, Akesson K, Benevolenskaya LI, Ferrari SL, Hallmans G, Hofman A, Husted LB, Kruk M, Kaptoge S, Karasik D, Karlsson MK, Lorentzon M, Masi L, McGuigan FE, Mellström D, Mosekilde L, Nogues X, Pols HA, Reeve J, Renner W, Rivadeneira F, van Schoor NM, Weber K, Ioannidis JP, Uitterlinden AG; GENOMOS Study. van Meurs JB, et al. JAMA. 2008 Mar 19;299(11):1277-90. doi: 10.1001/jama.299.11.1277. JAMA. 2008. PMID: 18349089 Free PMC article.
Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men.
Eriksson AL, Lorentzon M, Vandenput L, Labrie F, Lindersson M, Syvänen AC, Orwoll ES, Cummings SR, Zmuda JM, Ljunggren O, Karlsson MK, Mellström D, Ohlsson C. Eriksson AL, et al. Among authors: orwoll es. J Clin Endocrinol Metab. 2009 Mar;94(3):1033-41. doi: 10.1210/jc.2008-1283. Epub 2008 Dec 30. J Clin Endocrinol Metab. 2009. PMID: 19116238 Free PMC article.
351 results