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Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.
Eur Respir J. 2023 Sep 28;62(3):2202210. doi: 10.1183/13993003.02210-2022. Print 2023 Sep.
Eur Respir J. 2023.
PMID: 37442582
Free PMC article.
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
England E, Rees DG, Scott IC, Carmen S, Chan DTY, Chaillan Huntington CE, Houslay KF, Erngren T, Penney M, Majithiya JB, Rapley L, Sims DA, Hollins C, Hinchy EC, Strain MD, Kemp BP, Corkill DJ, May RD, Vousden KA, Butler RJ, Mustelin T, Vaughan TJ, Lowe DC, Colley C, Cohen ES.
England E, et al. Among authors: houslay kf.
Sci Rep. 2023 Jun 17;13(1):9825. doi: 10.1038/s41598-023-36642-y.
Sci Rep. 2023.
PMID: 37330528
Free PMC article.
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Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling.
Houslay KF, Fertig BA, Christian F, Tibbo AJ, Ling J, Findlay JE, Houslay MD, Baillie GS.
Houslay KF, et al.
J Biochem. 2019 Jul 1;166(1):97-106. doi: 10.1093/jb/mvz016.
J Biochem. 2019.
PMID: 30859186
Free PMC article.
Retracted.
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Prospects to translate the biology of IL-33 and ST2 during organ transplantation into therapeutics to treat graft-versus-host disease.
Scott IC, Houslay KF, Cohen ES.
Scott IC, et al. Among authors: houslay kf.
Ann Transl Med. 2016 Dec;4(24):500. doi: 10.21037/atm.2016.11.74.
Ann Transl Med. 2016.
PMID: 28149862
Free PMC article.
No abstract available.
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Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.
Houslay KF, Christian F, MacLeod R, Adams DR, Houslay MD, Baillie GS.
Houslay KF, et al.
Biochem J. 2017 Feb 15;474(4):597-609. doi: 10.1042/BCJ20160849. Epub 2016 Dec 19.
Biochem J. 2017.
PMID: 27993970
Free PMC article.
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Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation.
McGuire VA, Ruiz-Zorrilla Diez T, Emmerich CH, Strickson S, Ritorto MS, Sutavani RV, Weiβ A, Houslay KF, Knebel A, Meakin PJ, Phair IR, Ashford ML, Trost M, Arthur JS.
McGuire VA, et al. Among authors: houslay kf.
Sci Rep. 2016 Aug 8;6:31159. doi: 10.1038/srep31159.
Sci Rep. 2016.
PMID: 27498693
Free PMC article.
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