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Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1.
Khazan N, Quarato ER, Singh NA, Snyder CWA, Moore T, Miller JP, Yasui M, Teramoto Y, Goto T, Reshi S, Hong J, Zhang N, Pandey D, Srivastava P, Morell A, Kawano H, Kawano Y, Conley T, Sahasrabudhe DM, Yano N, Miyamoto H, Aljitawi O, Liesveld J, Becker MW, Calvi LM, Zhovmer AS, Tabdanov ED, Dokholyan NV, Linehan DC, Hansen JN, Gerber SA, Sharon A, Khera MK, Jurutka PW, Rochel N, Kim KK, Rowswell-Turner RB, Singh RK, Moore RG. Khazan N, et al. Among authors: dokholyan nv. Cancers (Basel). 2023 Jun 30;15(13):3432. doi: 10.3390/cancers15133432. Cancers (Basel). 2023. PMID: 37444542 Free PMC article.
Two-input protein logic gate for computation in living cells.
Vishweshwaraiah YL, Chen J, Chirasani VR, Tabdanov ED, Dokholyan NV. Vishweshwaraiah YL, et al. Among authors: dokholyan nv. Nat Commun. 2021 Nov 16;12(1):6615. doi: 10.1038/s41467-021-26937-x. Nat Commun. 2021. PMID: 34785644 Free PMC article.
Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo.
Khazan N, Kim KK, Hansen JN, Singh NA, Moore T, Snyder CWA, Pandita R, Strawderman M, Fujihara M, Takamura Y, Jian Y, Battaglia N, Yano N, Teramoto Y, Arnold LA, Hopson R, Kishor K, Nayak S, Ojha D, Sharon A, Ashton JM, Wang J, Milano MT, Miyamoto H, Linehan DC, Gerber SA, Kawar N, Singh AP, Tabdanov ED, Dokholyan NV, Kakuta H, Jurutka PW, Schor NF, Rowswell-Turner RB, Singh RK, Moore RG. Khazan N, et al. Among authors: dokholyan nv. J Med Chem. 2022 Apr 28;65(8):6039-6055. doi: 10.1021/acs.jmedchem.1c01878. Epub 2022 Apr 11. J Med Chem. 2022. PMID: 35404047 Free PMC article.
ASR490, a Small Molecule, Overrides Aberrant Expression of Notch1 in Colorectal Cancer.
Tyagi A, Chandrasekaran B, Kolluru V, Baby BV, Sripathi CA, Ankem MK, Ramisetti SR, Chirasani VR, Dokholyan NV, Sharma AK, Damodaran C. Tyagi A, et al. Among authors: dokholyan nv. Mol Cancer Ther. 2020 Dec;19(12):2422-2431. doi: 10.1158/1535-7163.MCT-19-0949. Epub 2020 Oct 21. Mol Cancer Ther. 2020. PMID: 33087513 Free PMC article.
Engineering an Allosteric Control of Protein Function.
Vishweshwaraiah YL, Chen J, Dokholyan NV. Vishweshwaraiah YL, et al. Among authors: dokholyan nv. J Phys Chem B. 2021 Feb 25;125(7):1806-1814. doi: 10.1021/acs.jpcb.0c11640. Epub 2021 Feb 10. J Phys Chem B. 2021. PMID: 33566608 Free PMC article. Review.
328 results