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1,076 results

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Page 1
Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian Randomization Study.
Zhang B, He R, Yao Z, Li P, Niu G, Yan Z, Zou Y, Tong X, Yang M. Zhang B, et al. Thromb Haemost. 2024 May 24. doi: 10.1055/s-0044-1786809. Online ahead of print. Thromb Haemost. 2024. PMID: 38788766
METHODS: In this MR analysis, summary statistics from a genome-wide association study meta-analysis of 91 inflammation-related proteins were integrated with independently sourced TAO data from the FinnGen consortium's R10 release. Methods such as inverse variance weighting …
METHODS: In this MR analysis, summary statistics from a genome-wide association study meta-analysis of 91 inflammation-related proteins were …
Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomisation.
Zhao SS, Mackie SL, Larsson SC, Burgess S, Yuan S. Zhao SS, et al. Rheumatology (Oxford). 2024 May 24:keae308. doi: 10.1093/rheumatology/keae308. Online ahead of print. Rheumatology (Oxford). 2024. PMID: 38788669
METHODS: We meta-analysed genetic association data from 8,156 cases of PMR (defined using diagnostic codes and self-report) and 416,495 controls of European ancestry from the UK Biobank and FinnGen. We then performed Mendelian randomization analyses to estimate the associa …
METHODS: We meta-analysed genetic association data from 8,156 cases of PMR (defined using diagnostic codes and self-report) and 416,495 cont …
Cholecystitis may decrease the risk of sudden death: A 2-sample Mendelian randomization study.
Zhang S, Sheng B, Xia S, Gao Y, Yan J. Zhang S, et al. Medicine (Baltimore). 2024 May 24;103(21):e38240. doi: 10.1097/MD.0000000000038240. Medicine (Baltimore). 2024. PMID: 38787985
We used large-scale genetic summary data from genome-wide association study, genetic summary statistics were sourced from 3 eminent repositories: the UK Biobank (N = 463,010), the FinnGen consortium (N = 215,027), and the European Bioinformatics Institute (N = 471,251). .. …
We used large-scale genetic summary data from genome-wide association study, genetic summary statistics were sourced from 3 eminent reposito …
Genome-Wide Investigation of Exogenous Female Hormones, Genetic Variation, and Venous Thromboembolism Risk.
Hasser EK, Brody JA, Bartz TM, Thibord F, Li-Gao R, Kauko A, Wiggins KL, Teder-Laving M, Kim J, Munsch G, Haile HG, Deleuze JF, van Hylckama Vlieg A, Wolberg AS, Boland A, Morange PE; FinnGen, Estonia Biobank research team; Kraft P, Lowenstein CJ, Emmerich J, Sitlani CM, Suchon P, Rosendaal FR, Niiranen T, Kabrhel C, Trégouët DA, Smith NL. Hasser EK, et al. J Thromb Haemost. 2024 May 21:S1538-7836(24)00294-0. doi: 10.1016/j.jtha.2024.05.011. Online ahead of print. J Thromb Haemost. 2024. PMID: 38782299
Association of sleep traits with risk of hypertensive disorders of pregnancy: a mendelian randomization study.
Zhao H, Wen P, Xu Q, Zi Y, Zheng X, Chen S, Qin Y, Shao S, Tu X, Zheng Z, Xiong Y, Li X. Zhao H, et al. J Hypertens. 2024 May 22. doi: 10.1097/HJH.0000000000003771. Online ahead of print. J Hypertens. 2024. PMID: 38780189
METHODS: Genome-wide association study (GWAS) summary statistics were obtained from the FinnGen consortium, UK Biobank, and other prominent consortia, with a focus on individuals of European ancestry. ...
METHODS: Genome-wide association study (GWAS) summary statistics were obtained from the FinnGen consortium, UK Biobank, and other pro …
The impact of neurocognitive and psychiatric disorders on the risk of idiopathic normal pressure hydrocephalus: A bidirectional Mendelian randomization study.
He Y, Wang Z, Zuo M, Zhang S, Li W, Chen S, Yuan Y, Yang Y, Liu Y. He Y, et al. Brain Behav. 2024 May;14(5):e3532. doi: 10.1002/brb3.3532. Brain Behav. 2024. PMID: 38779749 Free PMC article.
Genome-wide association studies (GWAS) of 12 neurocognitive and psychiatric disorders were downloaded via the OpenGWAS database, GWAS Catalog, and Psychiatric Genomics Consortium, whereas GWAS data of iNPH were obtained from the FinnGen consortium round 9 release, with 767 …
Genome-wide association studies (GWAS) of 12 neurocognitive and psychiatric disorders were downloaded via the OpenGWAS database, GWAS Catalo …
Exploration of potential novel drug targets for diabetic retinopathy by plasma proteome screening.
Yuan W, Xu W, Xu X, Qu B, Zhao F. Yuan W, et al. Sci Rep. 2024 May 22;14(1):11726. doi: 10.1038/s41598-024-62069-0. Sci Rep. 2024. PMID: 38778174 Free PMC article.
Genetic instruments for 734 plasma proteins were obtained from recently published genome-wide association studies (GWAS), and external plasma proteome data was retrieved from the Icelandic Decoding Genetics Study and UK Biobank Pharma Proteomics Project. Summary-level data of GWA …
Genetic instruments for 734 plasma proteins were obtained from recently published genome-wide association studies (GWAS), and external plasm …
Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.
Reeve MP, Vehviläinen M, Luo S, Ritari J, Karjalainen J, Gracia-Tabuenca J, Mehtonen J, Padmanabhuni SS, Kolosov N, Artomov M, Siirtola H, Olilla HM; FinnGen; Graham D, Partanen J, Xavier RJ, Daly MJ, Ripatti S, Salo T, Siponen M. Reeve MP, et al. Am J Hum Genet. 2024 May 15:S0002-9297(24)00161-7. doi: 10.1016/j.ajhg.2024.04.020. Online ahead of print. Am J Hum Genet. 2024. PMID: 38776927
We identified 15 genome-wide significant associations in FinnGen and an additional 12 when meta-analyzed with UKBB (27 independent associations at 25 distinct genomic locations), most of which are shared between oral and non-oral LP. Many associations coincide with known a …
We identified 15 genome-wide significant associations in FinnGen and an additional 12 when meta-analyzed with UKBB (27 independent as …
Inflammatory cytokines and their potential role in kidney stone disease: a Mendelian randomization study.
Yuan D, Yang J, Wu W, Amier Y, Li X, Wan W, Huang Y, Li J, Yu X. Yuan D, et al. Int Urol Nephrol. 2024 May 22. doi: 10.1007/s11255-024-04084-8. Online ahead of print. Int Urol Nephrol. 2024. PMID: 38776057
GWAS summary data related to KSD (9713 cases and 366,693 controls) were obtained from the FinnGen consortium. The primary MR analysis method was Inverse variance weighted. ...
GWAS summary data related to KSD (9713 cases and 366,693 controls) were obtained from the FinnGen consortium. The primary MR analysis …
Deep learning of left atrial structure and function provides link to atrial fibrillation risk.
Pirruccello JP, Di Achille P, Choi SH, Rämö JT, Khurshid S, Nekoui M, Jurgens SJ, Nauffal V, Kany S; FinnGen; Ng K, Friedman SF, Batra P, Lunetta KL, Palotie A, Philippakis AA, Ho JE, Lubitz SA, Ellinor PT. Pirruccello JP, et al. Nat Commun. 2024 May 21;15(1):4304. doi: 10.1038/s41467-024-48229-w. Nat Commun. 2024. PMID: 38773065 Free PMC article.
1,076 results