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The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.
Totland MZ, Knudsen LM, Rasmussen NL, Omori Y, Sørensen V, Elster VCW, Stenersen JM, Larsen M, Jensen CL, Zickfeldt Lade AA, Bruusgaard E, Basing S, Kryeziu K, Brech A, Aasen T, Lothe RA, Leithe E. Totland MZ, et al. Among authors: kryeziu k. Cell Mol Life Sci. 2024 Apr 10;81(1):171. doi: 10.1007/s00018-024-05165-8. Cell Mol Life Sci. 2024. PMID: 38597989 Free PMC article.
Endocytic trafficking of connexins in cancer pathogenesis.
Totland MZ, Omori Y, Sørensen V, Kryeziu K, Aasen T, Brech A, Leithe E. Totland MZ, et al. Among authors: kryeziu k. Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166812. doi: 10.1016/j.bbadis.2023.166812. Epub 2023 Jul 16. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 37454772 Free article. Review.
A novel EGFR inhibitor acts as potent tool for hypoxia-activated prodrug systems and exerts strong synergistic activity with VEGFR inhibition in vitro and in vivo.
Caban M, Koblmueller B, Groza D, Schueffl HH, Terenzi A, Tolios A, Mohr T, Mathuber M, Kryeziu K, Jaunecker C, Pirker C, Keppler BK, Berger W, Kowol CR, Heffeter P. Caban M, et al. Among authors: kryeziu k. Cancer Lett. 2023 Jul 1;565:216237. doi: 10.1016/j.canlet.2023.216237. Epub 2023 May 19. Cancer Lett. 2023. PMID: 37211067 Free article.
The expressed mutational landscape of microsatellite stable colorectal cancers.
Sveen A, Johannessen B, Eilertsen IA, Røsok BI, Gulla M, Eide PW, Bruun J, Kryeziu K, Meza-Zepeda LA, Myklebost O, Bjørnbeth BA, Skotheim RI, Nesbakken A, Lothe RA. Sveen A, et al. Among authors: kryeziu k. Genome Med. 2021 Sep 1;13(1):142. doi: 10.1186/s13073-021-00955-2. Genome Med. 2021. PMID: 34470667 Free PMC article.
Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity.
Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A. Smeby J, et al. Among authors: kryeziu k. EBioMedicine. 2020 Sep;59:102923. doi: 10.1016/j.ebiom.2020.102923. Epub 2020 Aug 13. EBioMedicine. 2020. PMID: 32799124 Free PMC article.
Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity.
Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok B, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA. Bruun J, et al. Among authors: kryeziu k. Clin Cancer Res. 2020 Aug 1;26(15):4107-4119. doi: 10.1158/1078-0432.CCR-19-3637. Epub 2020 Apr 16. Clin Cancer Res. 2020. PMID: 32299813
Combination therapies with HSP90 inhibitors against colorectal cancer.
Kryeziu K, Bruun J, Guren TK, Sveen A, Lothe RA. Kryeziu K, et al. Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):240-247. doi: 10.1016/j.bbcan.2019.01.002. Epub 2019 Jan 30. Biochim Biophys Acta Rev Cancer. 2019. PMID: 30708039 Free article. Review.
28 results