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The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ. Pharaoh G, et al. Among authors: qian wj. Geroscience. 2023 Dec;45(6):3529-3548. doi: 10.1007/s11357-023-00861-y. Epub 2023 Jul 18. Geroscience. 2023. PMID: 37462785 Free PMC article.
Using the CPTAC Assay Portal to Identify and Implement Highly Characterized Targeted Proteomics Assays.
Whiteaker JR, Halusa GN, Hoofnagle AN, Sharma V, MacLean B, Yan P, Wrobel JA, Kennedy J, Mani DR, Zimmerman LJ, Meyer MR, Mesri M, Boja E, Carr SA, Chan DW, Chen X, Chen J, Davies SR, Ellis MJ, Fenyö D, Hiltke T, Ketchum KA, Kinsinger C, Kuhn E, Liebler DC, Liu T, Loss M, MacCoss MJ, Qian WJ, Rivers R, Rodland KD, Ruggles KV, Scott MG, Smith RD, Thomas S, Townsend RR, Whiteley G, Wu C, Zhang H, Zhang Z, Rodriguez H, Paulovich AG. Whiteaker JR, et al. Among authors: qian wj. Methods Mol Biol. 2016;1410:223-36. doi: 10.1007/978-1-4939-3524-6_13. Methods Mol Biol. 2016. PMID: 26867747 Free PMC article.
Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice.
Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Merrihew GE, Egertson JD, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, MacCoss MJ, Qian WJ, Marcinek DJ. Campbell MD, et al. Among authors: qian wj. Free Radic Biol Med. 2019 Apr;134:268-281. doi: 10.1016/j.freeradbiomed.2018.12.031. Epub 2018 Dec 28. Free Radic Biol Med. 2019. PMID: 30597195 Free PMC article.
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice.
Chiao YA, Zhang H, Sweetwyne M, Whitson J, Ting YS, Basisty N, Pino LK, Quarles E, Nguyen NH, Campbell MD, Zhang T, Gaffrey MJ, Merrihew G, Wang L, Yue Y, Duan D, Granzier HL, Szeto HH, Qian WJ, Marcinek D, MacCoss MJ, Rabinovitch P. Chiao YA, et al. Among authors: qian wj. Elife. 2020 Jul 10;9:e55513. doi: 10.7554/eLife.55513. Elife. 2020. PMID: 32648542 Free PMC article.
Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.
Whitson JA, Martín-Pérez M, Zhang T, Gaffrey MJ, Merrihew GE, Huang E, White CC, Kavanagh TJ, Qian WJ, Campbell MD, MacCoss MJ, Marcinek DJ, Villén J, Rabinovitch PS. Whitson JA, et al. Among authors: qian wj. Geroscience. 2021 Oct;43(5):2395-2412. doi: 10.1007/s11357-021-00447-6. Epub 2021 Sep 4. Geroscience. 2021. PMID: 34480713 Free PMC article.
Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice.
Campbell MD, Martín-Pérez M, Egertson JD, Gaffrey MJ, Wang L, Bammler T, Rabinovitch PS, MacCoss M, Qian WJ, Villen J, Marcinek D. Campbell MD, et al. Among authors: qian wj. Geroscience. 2022 Dec;44(6):2913-2924. doi: 10.1007/s11357-022-00679-0. Epub 2022 Nov 2. Geroscience. 2022. PMID: 36322234 Free PMC article.
Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA).
Day NJ, Kelly SS, Lui LY, Mansfield TA, Gaffrey MJ, Trejo JB, Sagendorf TJ, Attah K, Moore RJ, Douglas CM, Newman AB, Kritchevsky SB, Kramer PA, Marcinek DJ, Coen PM, Goodpaster BH, Hepple RT, Cawthon PM, Petyuk VA, Esser KA, Qian WJ, Cummings SR. Day NJ, et al. Among authors: qian wj. medRxiv [Preprint]. 2023 Nov 8:2023.11.07.23298224. doi: 10.1101/2023.11.07.23298224. medRxiv. 2023. PMID: 37986748 Free PMC article. Updated. Preprint.
Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA).
Day NJ, Kelly SS, Lui LY, Mansfield TA, Gaffrey MJ, Trejo JB, Sagendorf TJ, Attah IK, Moore RJ, Douglas CM, Newman AB, Kritchevsky SB, Kramer PA, Marcinek DJ, Coen PM, Goodpaster BH, Hepple RT, Cawthon PM, Petyuk VA, Esser KA, Qian WJ, Cummings SR. Day NJ, et al. Among authors: qian wj. Aging Cell. 2024 Feb 8:e14094. doi: 10.1111/acel.14094. Online ahead of print. Aging Cell. 2024. PMID: 38332629 Free article.
293 results