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The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy.
McMyn NF, Varriale J, Fray EJ, Zitzmann C, MacLeod H, Lai J, Singhal A, Moskovljevic M, Garcia MA, Lopez BM, Hariharan V, Rhodehouse K, Lynn K, Tebas P, Mounzer K, Montaner LJ, Benko E, Kovacs C, Hoh R, Simonetti FR, Laird GM, Deeks SG, Ribeiro RM, Perelson AS, Siliciano RF, Siliciano JM. McMyn NF, et al. Among authors: simonetti fr. J Clin Invest. 2023 Sep 1;133(17):e171554. doi: 10.1172/JCI171554. J Clin Invest. 2023. PMID: 37463049 Free PMC article.
The role of CD32 during HIV-1 infection.
Bertagnolli LN, White JA, Simonetti FR, Beg SA, Lai J, Tomescu C, Murray AJ, Antar AAR, Zhang H, Margolick JB, Hoh R, Deeks SG, Tebas P, Montaner LJ, Siliciano RF, Laird GM, Siliciano JD. Bertagnolli LN, et al. Among authors: simonetti fr. Nature. 2018 Sep;561(7723):E17-E19. doi: 10.1038/s41586-018-0494-3. Epub 2018 Sep 19. Nature. 2018. PMID: 30232425 Free PMC article.
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.
Bruner KM, Wang Z, Simonetti FR, Bender AM, Kwon KJ, Sengupta S, Fray EJ, Beg SA, Antar AAR, Jenike KM, Bertagnolli LN, Capoferri AA, Kufera JT, Timmons A, Nobles C, Gregg J, Wada N, Ho YC, Zhang H, Margolick JB, Blankson JN, Deeks SG, Bushman FD, Siliciano JD, Laird GM, Siliciano RF. Bruner KM, et al. Among authors: simonetti fr. Nature. 2019 Feb;566(7742):120-125. doi: 10.1038/s41586-019-0898-8. Epub 2019 Jan 30. Nature. 2019. PMID: 30700913 Free PMC article.
The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections.
Bender AM, Simonetti FR, Kumar MR, Fray EJ, Bruner KM, Timmons AE, Tai KY, Jenike KM, Antar AAR, Liu PT, Ho YC, Raugi DN, Seydi M, Gottlieb GS, Okoye AA, Del Prete GQ, Picker LJ, Mankowski JL, Lifson JD, Siliciano JD, Laird GM, Barouch DH, Clements JE, Siliciano RF. Bender AM, et al. Among authors: simonetti fr. Cell Host Microbe. 2019 Jul 10;26(1):73-85.e4. doi: 10.1016/j.chom.2019.06.005. Cell Host Microbe. 2019. PMID: 31295427 Free PMC article.
'Rinse and Replace': Boosting T Cell Turnover To Reduce HIV-1 Reservoirs.
Grossman Z, Singh NJ, Simonetti FR, Lederman MM, Douek DC, Deeks SG; Contributing authors. Grossman Z, et al. Among authors: simonetti fr. Trends Immunol. 2020 Jun;41(6):466-480. doi: 10.1016/j.it.2020.04.003. Epub 2020 May 12. Trends Immunol. 2020. PMID: 32414695 Review.
Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA.
Simonetti FR, White JA, Tumiotto C, Ritter KD, Cai M, Gandhi RT, Deeks SG, Howell BJ, Montaner LJ, Blankson JN, Martin A, Laird GM, Siliciano RF, Mellors JW, Siliciano JD. Simonetti FR, et al. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18692-18700. doi: 10.1073/pnas.2006816117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690683 Free PMC article.
Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1.
Bertagnolli LN, Varriale J, Sweet S, Brockhurst J, Simonetti FR, White J, Beg S, Lynn K, Mounzer K, Frank I, Tebas P, Bar KJ, Montaner LJ, Siliciano RF, Siliciano JD. Bertagnolli LN, et al. Among authors: simonetti fr. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32066-32077. doi: 10.1073/pnas.2020617117. Epub 2020 Nov 25. Proc Natl Acad Sci U S A. 2020. PMID: 33239444 Free PMC article.
Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4+ T cells in vivo.
Simonetti FR, Zhang H, Soroosh GP, Duan J, Rhodehouse K, Hill AL, Beg SA, McCormick K, Raymond HE, Nobles CL, Everett JK, Kwon KJ, White JA, Lai J, Margolick JB, Hoh R, Deeks SG, Bushman FD, Siliciano JD, Siliciano RF. Simonetti FR, et al. J Clin Invest. 2021 Feb 1;131(3):e145254. doi: 10.1172/JCI145254. J Clin Invest. 2021. PMID: 33301425 Free PMC article.
45 results