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RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.
Longo MA, Roy S, Chen Y, Tomaszowski KH, Arvai AS, Pepper JT, Boisvert RA, Kunnimalaiyaan S, Keshvani C, Schild D, Bacolla A, Williams GJ, Tainer JA, Schlacher K. Longo MA, et al. Among authors: bacolla a. Nat Commun. 2023 Jul 24;14(1):4445. doi: 10.1038/s41467-023-40096-1. Nat Commun. 2023. PMID: 37488098 Free PMC article.
A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy.
Townley BA, Buerer L, Tsao N, Bacolla A, Mansoori F, Rusanov T, Clark N, Goodarzi N, Schmidt N, Srivatsan SN, Sun H, Sample RA, Brickner JR, McDonald D, Tsai MS, Walter MJ, Wozniak DF, Holehouse AS, Pena V, Tainer JA, Fairbrother WG, Mosammaparast N. Townley BA, et al. Among authors: bacolla a. Mol Cell. 2023 Jul 6;83(13):2258-2275.e11. doi: 10.1016/j.molcel.2023.06.011. Epub 2023 Jun 26. Mol Cell. 2023. PMID: 37369199
ASCC1 structures and bioinformatics reveal a novel Helix-Clasp-Helix RNA-binding motif linked to a two-histidine phosphodiesterase.
Chinnam NB, Thapar R, Arvai AS, Sarker AH, Soll JM, Paul T, Syed A, Rosenberg DJ, Hammel M, Bacolla A, Katsonis P, Asthana A, Tsai MS, Ivanov I, Lichtarge O, Silverman RH, Mosammaparast N, Tsutakawa SE, Tainer JA. Chinnam NB, et al. Among authors: bacolla a. J Biol Chem. 2024 May 13:107368. doi: 10.1016/j.jbc.2024.107368. Online ahead of print. J Biol Chem. 2024. PMID: 38750793 Free article.
Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
Syed A, Filandr F, Patterson-Fortin J, Bacolla A, Ravindranathan R, Zhou J, McDonald DT, Albuhluli ME, Verway-Cohen A, Newman JA, Tsai MS, Jones DE, Schriemer DC, D'Andrea AD, Tainer JA. Syed A, et al. Among authors: bacolla a. Nucleic Acids Res. 2023 Oct 13;51(18):9920-9937. doi: 10.1093/nar/gkad727. Nucleic Acids Res. 2023. PMID: 37665033 Free PMC article.
85 results