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Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease.
Prokopiou PC, Engels-Domínguez N, Schultz AP, Sepulcre J, Koops EA, Papp KV, Marshall GA, Normandin MD, El Fakhri G, Rentz D, Sperling RA, Johnson KA, Jacobs HIL. Prokopiou PC, et al. Among authors: engels dominguez n. Neurology. 2023 Sep 19;101(12):e1206-e1217. doi: 10.1212/WNL.0000000000207646. Epub 2023 Jul 25. Neurology. 2023. PMID: 37491329
Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals.
Prokopiou PC, Engels-Domínguez N, Papp KV, Scott MR, Schultz AP, Schneider C, Farrell ME, Buckley RF, Quiroz YT, El Fakhri G, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Prokopiou PC, et al. Among authors: engels dominguez n. Nat Commun. 2022 Mar 23;13(1):1571. doi: 10.1038/s41467-022-28986-2. Nat Commun. 2022. PMID: 35322012 Free PMC article.
Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease.
Jacobs HIL, Becker JA, Kwong K, Munera D, Ramirez-Gomez L, Engels-Domínguez N, Sanchez JS, Vila-Castelar C, Baena A, Sperling RA, Johnson KA, Lopera F, Quiroz YT. Jacobs HIL, et al. Among authors: engels dominguez n. Alzheimers Dement. 2023 Jan;19(1):169-180. doi: 10.1002/alz.12656. Epub 2022 Mar 17. Alzheimers Dement. 2023. PMID: 35298083 Free PMC article.
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline.
Jacobs HIL, Becker JA, Kwong K, Engels-Domínguez N, Prokopiou PC, Papp KV, Properzi M, Hampton OL, d'Oleire Uquillas F, Sanchez JS, Rentz DM, El Fakhri G, Normandin MD, Price JC, Bennett DA, Sperling RA, Johnson KA. Jacobs HIL, et al. Among authors: engels dominguez n. Sci Transl Med. 2021 Sep 22;13(612):eabj2511. doi: 10.1126/scitranslmed.abj2511. Epub 2021 Sep 22. Sci Transl Med. 2021. PMID: 34550726 Free PMC article.