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Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.
Martinez Lagunas K, Savcigil DP, Zrilic M, Carvajal Fraile C, Craxton A, Self E, Uranga-Murillo I, de Miguel D, Arias M, Willenborg S, Piekarek M, Albert MC, Nugraha K, Lisewski I, Janakova E, Igual N, Tonnus W, Hildebrandt X, Ibrahim M, Ballegeer M, Saelens X, Kueh A, Meier P, Linkermann A, Pardo J, Eming S, Walczak H, MacFarlane M, Peltzer N, Annibaldi A. Martinez Lagunas K, et al. Among authors: peltzer n. Sci Adv. 2023 Jul 28;9(30):eadg2829. doi: 10.1126/sciadv.adg2829. Epub 2023 Jul 26. Sci Adv. 2023. PMID: 37494451 Free PMC article.
Ubiquitin in the immune system.
Zinngrebe J, Montinaro A, Peltzer N, Walczak H. Zinngrebe J, et al. Among authors: peltzer n. EMBO Rep. 2014 Jan;15(1):28-45. doi: 10.1002/embr.201338025. Epub 2013 Dec 27. EMBO Rep. 2014. PMID: 24375678 Free PMC article. Review.
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.
Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J. Rickard JA, et al. Among authors: peltzer n. Elife. 2014 Dec 2;3:e03464. doi: 10.7554/eLife.03464. Elife. 2014. PMID: 25443632 Free PMC article.
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling.
Peltzer N, Darding M, Walczak H. Peltzer N, et al. Trends Cell Biol. 2016 Jun;26(6):445-461. doi: 10.1016/j.tcb.2016.01.006. Epub 2016 Feb 11. Trends Cell Biol. 2016. PMID: 26877205 Review.
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, Sarr A, Darding M, Draber P, Haas TL, Akarca A, Marafioti T, Pasparakis M, Bertin J, Gough PJ, Bouillet P, Strasser A, Leverkus M, Silke J, Walczak H. Taraborrelli L, et al. Among authors: peltzer n. Nat Commun. 2018 Sep 25;9(1):3910. doi: 10.1038/s41467-018-06155-8. Nat Commun. 2018. PMID: 30254289 Free PMC article.
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke H, Fava LL, Haschka MD, Glatter T, Nesvizhskii A, Schmidt A, Harris PA, Bertin J, Gough PJ, Villunger A, Silke J, Pasparakis M, Bianchi K, Meier P. Liccardi G, et al. Among authors: peltzer n. Mol Cell. 2019 Feb 7;73(3):413-428.e7. doi: 10.1016/j.molcel.2018.11.010. Epub 2018 Dec 28. Mol Cell. 2019. PMID: 30598363 Free PMC article.
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