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The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.
Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, Shklyar B, Joannas L, Mustone N, Sherman S, Ward D, Houghton J, Baer CE, O'Hara A, Henao-Mejia J, Hoebe K, Fitzgerald KA. Shmuel-Galia L, et al. Among authors: fitzgerald ka. Cell Metab. 2023 Aug 8;35(8):1441-1456.e9. doi: 10.1016/j.cmet.2023.06.019. Epub 2023 Jul 25. Cell Metab. 2023. PMID: 37494932
The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.
Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, O'Hara Hall A, Hoebe K, Fitzgerald KA. Vierbuchen T, et al. Among authors: fitzgerald ka. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2213715120. doi: 10.1073/pnas.2213715120. Epub 2022 Dec 28. Proc Natl Acad Sci U S A. 2023. PMID: 36577072 Free PMC article.
PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection.
Baran M, Feriotti C, McGinley A, Carlile SR, Jiang Z, Calderon-Gonzalez R, Dumigan A, Sá-Pessoa J, Sutton CE, Kearney J, McLoughlin RM, Mills KHG, Fitzgerald KA, Bengeochea JA, Bowie AG. Baran M, et al. Among authors: fitzgerald ka. Cell Rep. 2023 Apr 25;42(4):112341. doi: 10.1016/j.celrep.2023.112341. Epub 2023 Apr 4. Cell Rep. 2023. PMID: 37018072 Free article.
Development of LB244, an Irreversible STING Antagonist.
Barasa L, Chaudhuri S, Zhou JY, Jiang Z, Choudhary S, Green RM, Wiggin E, Cameron M, Humphries F, Fitzgerald KA, Thompson PR. Barasa L, et al. Among authors: fitzgerald ka. J Am Chem Soc. 2023 Sep 20;145(37):20273-20288. doi: 10.1021/jacs.3c03637. Epub 2023 Sep 11. J Am Chem Soc. 2023. PMID: 37695732
Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates.
Chen Y, Lei X, Jiang Z, Humphries F, Parsi KM, Mustone NJ, Ramos I, Mutetwa T, Fernandez-Sesma A, Maehr R, Caffrey DR, Fitzgerald KA. Chen Y, et al. Among authors: fitzgerald ka. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2308355120. doi: 10.1073/pnas.2308355120. Epub 2023 Nov 14. Proc Natl Acad Sci U S A. 2023. PMID: 37963251 Free PMC article.
Lnc-ing RNA to intestinal homeostasis and inflammation.
Fitzgerald KA, Shmuel-Galia L. Fitzgerald KA, et al. Trends Immunol. 2024 Feb;45(2):127-137. doi: 10.1016/j.it.2023.12.005. Epub 2024 Jan 13. Trends Immunol. 2024. PMID: 38220553 Review.
Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease.
Johnson JL, Sargsyan D, Neiman EM, Hart A, Stojmirovic A, Kosoy R, Irizar H, Suárez-Fariñas M, Song WM, Argmann C, Avey S, Shmuel-Galia L, Vierbuchen T, Bongers G, Sun Y, Edelstein L, Perrigoue J, Towne JE, Hall AO, Fitzgerald KA, Hoebe K. Johnson JL, et al. Among authors: fitzgerald ka. JCI Insight. 2024 Feb 8;9(3):e168988. doi: 10.1172/jci.insight.168988. JCI Insight. 2024. PMID: 38329124 Free PMC article.
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Hariharan VN, et al. Among authors: fitzgerald ka. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2219523120. doi: 10.1073/pnas.2219523120. Epub 2023 Mar 9. Proc Natl Acad Sci U S A. 2023. PMID: 36893269 Free PMC article.
STING channels its proton power.
Dong M, Fitzgerald KA. Dong M, et al. Among authors: fitzgerald ka. Mol Cell. 2023 Oct 5;83(19):3402-3403. doi: 10.1016/j.molcel.2023.09.014. Mol Cell. 2023. PMID: 37802022
357 results