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Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex-vivo perfusion of GTKO pig lungs with human blood.
Chaban R, McGrath G, Habibabady Z, Rosales I, Burdorf L, Ayares DL, Rybak E, Zhang T, Harris DG, Dahi S, Ali F, Parsell DM, Braileanu G, Cheng X, Sievert E, Phelps C, Azimzadeh AM, Pierson RN 3rd. Chaban R, et al. Among authors: parsell dm. Xenotransplantation. 2023 Jul-Aug;30(4):e12812. doi: 10.1111/xen.12812. Epub 2023 Jul 28. Xenotransplantation. 2023. PMID: 37504492
Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor.
Burdorf L, Riner A, Rybak E, Salles II, De Meyer SF, Shah A, Quinn KJ, Harris D, Zhang T, Parsell D, Ali F, Schwartz E, Kang E, Cheng X, Sievert E, Zhao Y, Braileanu G, Phelps CJ, Ayares DL, Deckmyn H, Pierson RN 3rd, Azimzadeh AM, Dandro A, Karavi K. Burdorf L, et al. Xenotransplantation. 2016 May;23(3):222-236. doi: 10.1111/xen.12236. Epub 2016 May 18. Xenotransplantation. 2016. PMID: 27188532 Free PMC article.
N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.
Cimeno A, Hassanein W, French BM, Powell JM, Burdorf L, Goloubeva O, Cheng X, Parsell DM, Ramsoondar J, Kuravi K, Vaught T, Uluer MC, Redding E, O'Neill N, Laird C, Hershfeld A, Tatarov I, Thomas K, Ayares D, Azimzadeh AM, Pierson RN 3rd, Barth RN, LaMattina JC. Cimeno A, et al. Among authors: parsell dm. Xenotransplantation. 2017 Nov;24(6):10.1111/xen.12339. doi: 10.1111/xen.12339. Epub 2017 Sep 22. Xenotransplantation. 2017. PMID: 28940313 Free PMC article.
Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood.
Burdorf L, Harris D, Dahi S, Laird C, Zhang T, Ali F, Shah A, Thompson M, Braileanu G, Cheng X, Sievert E, Schwartz E, Sendil S, Parsell DM, Redding E, Phelps CJ, Ayares DL, Azimzadeh AM, Pierson RN 3rd. Burdorf L, et al. Among authors: parsell dm. Xenotransplantation. 2019 Mar;26(2):e12458. doi: 10.1111/xen.12458. Epub 2018 Sep 3. Xenotransplantation. 2019. PMID: 30175863 Free PMC article.
P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage.
Laird CT, Hassanein W, O'Neill NA, French BM, Cheng X, Fogler WE, Magnani JL, Parsell D, Cimeno A, Phelps CJ, Ayares D, Burdorf L, Azimzadeh AM, Pierson RN 3rd. Laird CT, et al. Xenotransplantation. 2018 Mar;25(2):e12381. doi: 10.1111/xen.12381. Epub 2018 Jan 23. Xenotransplantation. 2018. PMID: 29359469 Free PMC article.
hEPCR.hTBM.hCD47.hHO-1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood.
Cimeno A, Kuravi K, Sorrells L, Dandro A, Sendil S, Burdorf L, Parsell DM, Eyestone W, Phelps C, Ayares D, Azimzadeh AM, Pierson RN 3rd, Barth RN, LaMattina JC. Cimeno A, et al. Among authors: parsell dm. Xenotransplantation. 2022 Mar;29(2):e12731. doi: 10.1111/xen.12731. Epub 2022 Feb 15. Xenotransplantation. 2022. PMID: 35166407 Free PMC article.
14 results