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Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder.
Muhie S, Gautam A, Misganaw B, Yang R, Mellon SH, Hoke A, Flory J, Daigle B, Swift K; PTSD Systems Biology Consortium; Hood L, Doyle FJ 3rd, Wolkowitz OM, Marmar CR, Ressler K, Yehuda R, Hammamieh R, Jett M. Muhie S, et al. Among authors: yang r. Brain Behav Immun. 2023 Oct;113:303-316. doi: 10.1016/j.bbi.2023.07.015. Epub 2023 Jul 27. Brain Behav Immun. 2023. PMID: 37516387 Free article.
Systems biology approach to understanding post-traumatic stress disorder.
Thakur GS, Daigle BJ Jr, Dean KR, Zhang Y, Rodriguez-Fernandez M, Hammamieh R, Yang R, Jett M, Palma J, Petzold LR, Doyle FJ 3rd. Thakur GS, et al. Among authors: yang r. Mol Biosyst. 2015 Apr;11(4):980-93. doi: 10.1039/c4mb00404c. Mol Biosyst. 2015. PMID: 25627823 Review.
A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.
Almli LM, Stevens JS, Smith AK, Kilaru V, Meng Q, Flory J, Abu-Amara D, Hammamieh R, Yang R, Mercer KB, Binder EB, Bradley B, Hamilton S, Jett M, Yehuda R, Marmar CR, Ressler KJ. Almli LM, et al. Among authors: yang r. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul;168B(5):327-36. doi: 10.1002/ajmg.b.32315. Epub 2015 May 18. Am J Med Genet B Neuropsychiatr Genet. 2015. PMID: 25988933 Free PMC article.
Whole-genome DNA methylation status associated with clinical PTSD measures of OIF/OEF veterans.
Hammamieh R, Chakraborty N, Gautam A, Muhie S, Yang R, Donohue D, Kumar R, Daigle BJ Jr, Zhang Y, Amara DA, Miller SA, Srinivasan S, Flory J, Yehuda R, Petzold L, Wolkowitz OM, Mellon SH, Hood L, Doyle FJ 3rd, Marmar C, Jett M. Hammamieh R, et al. Among authors: yang r. Transl Psychiatry. 2017 Jul 11;7(7):e1169. doi: 10.1038/tp.2017.129. Transl Psychiatry. 2017. PMID: 28696412 Free PMC article.
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