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Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.
Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. Rawat V, et al. Among authors: harris is. bioRxiv [Preprint]. 2023 Jul 28:2023.07.26.550731. doi: 10.1101/2023.07.26.550731. bioRxiv. 2023. PMID: 37546939 Free PMC article. Preprint.
Glutathione supports lipid abundance in vivo.
Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Duncan R, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith Z, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Asantewaa G, et al. Among authors: harris is. bioRxiv [Preprint]. 2023 Feb 11:2023.02.10.524960. doi: 10.1101/2023.02.10.524960. bioRxiv. 2023. PMID: 36798186 Free PMC article. Preprint.
Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation.
Raymonda MH, Rodríguez-Sánchez I, Schafer XL, Smorodintsev-Schiller L, Harris IS, Munger J. Raymonda MH, et al. Among authors: harris is. bioRxiv [Preprint]. 2023 May 17:2023.05.17.541212. doi: 10.1101/2023.05.17.541212. bioRxiv. 2023. PMID: 37292722 Free PMC article. Updated. Preprint.
Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.
Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris I, Sept D, Mason FM, Coloff JL. Rawat V, et al. JCI Insight. 2024 May 30:e174329. doi: 10.1172/jci.insight.174329. Online ahead of print. JCI Insight. 2024. PMID: 38815134 Free article.
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation.
Bonetti L, Horkova V, Longworth J, Guerra L, Kurniawan H, Franchina DG, Soriano-Baguet L, Grusdat M, Spath S, Koncina E, Ewen A, Binsfeld C, Verschueren C, Gérardy JJ, Kobayashi T, Dostert C, Farinelle S, Härm J, Chen Y, Harris IS, Lang PA, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. Bonetti L, et al. Among authors: harris is. bioRxiv [Preprint]. 2023 Jul 7:2023.07.06.547932. doi: 10.1101/2023.07.06.547932. bioRxiv. 2023. PMID: 37489135 Free PMC article. Preprint.
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress.
Do BT, Hsu PP, Vermeulen SY, Wang Z, Hirz T, Abbott KL, Aziz N, Replogle JM, Bjelosevic S, Paolino J, Nelson SA, Block S, Darnell AM, Ferreira R, Zhang H, Milosevic J, Schmidt DR, Chidley C, Harris IS, Weissman JS, Pikman Y, Stegmaier K, Cheloufi S, Su XA, Sykes DB, Vander Heiden MG. Do BT, et al. Among authors: harris is. Dev Cell. 2024 May 30:S1534-5807(24)00327-7. doi: 10.1016/j.devcel.2024.05.010. Online ahead of print. Dev Cell. 2024. PMID: 38823395
Double Whammy Complicating Management of Pulmonary Hypertension.
Salahuddin A, Harris IS, Sabanayagam A. Salahuddin A, et al. Among authors: harris is. Circulation. 2024 May 28;149(22):1770-1774. doi: 10.1161/CIRCULATIONAHA.123.066807. Epub 2024 May 28. Circulation. 2024. PMID: 38805576 No abstract available.
Regulation of antioxidants in cancer.
Hecht F, Zocchi M, Alimohammadi F, Harris IS. Hecht F, et al. Among authors: harris is. Mol Cell. 2024 Jan 4;84(1):23-33. doi: 10.1016/j.molcel.2023.11.001. Epub 2023 Nov 28. Mol Cell. 2024. PMID: 38029751 Review.
77 results