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Page 1
Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.
Guirguis AA, Ofir-Rosenfeld Y, Knezevic K, Blackaby W, Hardick D, Chan YC, Motazedian A, Gillespie A, Vassiliadis D, Lam EYN, Tran K, Andrews B, Harbour ME, Vasiliauskaite L, Saunders CJ, Tsagkogeorga G, Azevedo A, Obacz J, Pilka ES, Carkill M, MacPherson L, Wainwright EN, Liddicoat B, Blyth BJ, Albertella MR, Rausch O, Dawson MA. Guirguis AA, et al. Among authors: obacz j. Cancer Discov. 2023 Oct 5;13(10):2228-2247. doi: 10.1158/2159-8290.CD-23-0007. Cancer Discov. 2023. PMID: 37548590
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.
Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jäger R, Gorman AM, Samali A. Logue SE, et al. Among authors: obacz j. Nat Commun. 2018 Aug 15;9(1):3267. doi: 10.1038/s41467-018-05763-8. Nat Commun. 2018. PMID: 30111846 Free PMC article.
Biological basis for novel mesothelioma therapies.
Obacz J, Yung H, Shamseddin M, Linnane E, Liu X, Azad AA, Rassl DM, Fairen-Jimenez D, Rintoul RC, Nikolić MZ, Marciniak SJ. Obacz J, et al. Br J Cancer. 2021 Oct;125(8):1039-1055. doi: 10.1038/s41416-021-01462-2. Epub 2021 Jul 5. Br J Cancer. 2021. PMID: 34226685 Free PMC article. Review.
Enhancing Drug Delivery Efficacy Through Bilayer Coating of Zirconium-Based Metal-Organic Frameworks: Sustained Release and Improved Chemical Stability and Cellular Uptake for Cancer Therapy.
Liu X, Obacz J, Emanuelli G, Chambers JE, Abreu S, Chen X, Linnane E, Mehta JP, Wheatley AEH, Marciniak SJ, Fairen-Jimenez D. Liu X, et al. Among authors: obacz j. Chem Mater. 2024 Apr 11;36(8):3588-3603. doi: 10.1021/acs.chemmater.3c02954. eCollection 2024 Apr 23. Chem Mater. 2024. PMID: 38681089 Free PMC article.
Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma.
Obacz J, Valer JA, Nibhani R, Adams TS, Schupp JC, Veale N, Lewis-Wade A, Flint J, Hogan J, Aresu G, Coonar AS, Peryt A, Biffi G, Kaminski N, Francies H, Rassl DM, Garnett MJ, Rintoul RC, Marciniak SJ. Obacz J, et al. Eur Respir J. 2024 Jan 25;63(1):2300143. doi: 10.1183/13993003.00143-2023. Print 2024 Jan. Eur Respir J. 2024. PMID: 38212075 Free PMC article.
IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma.
Obacz J, Archambeau J, Lafont E, Nivet M, Martin S, Aubry M, Voutetakis K, Pineau R, Boniface R, Sicari D, Pelizzari-Raymundo D, Ghukasyan G, McGrath E, Vlachavas EI, Le Gallo M, Le Reste PJ, Barroso K, Fainsod-Levi T, Obiedat A, Granot Z, Tirosh B, Samal J, Pandit A, Négroni L, Soriano N, Monnier A, Mosser J, Chatziioannou A, Quillien V, Chevet E, Avril T. Obacz J, et al. Neuro Oncol. 2024 May 3;26(5):858-871. doi: 10.1093/neuonc/noad256. Neuro Oncol. 2024. PMID: 38153426
Dual IRE1 RNase functions dictate glioblastoma development.
Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E. Lhomond S, et al. Among authors: obacz j. EMBO Mol Med. 2023 Feb 8;15(2):e16731. doi: 10.15252/emmm.202216731. EMBO Mol Med. 2023. PMID: 36752056 Free PMC article.
Dual IRE1 RNase functions dictate glioblastoma development.
Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E. Lhomond S, et al. Among authors: obacz j. EMBO Mol Med. 2022 Feb 7;14(2):e15622. doi: 10.15252/emmm.202115622. Epub 2022 Jan 11. EMBO Mol Med. 2022. PMID: 35014200 Free PMC article.
Use of preclinical models for malignant pleural mesothelioma.
Shamseddin M, Obacz J, Garnett MJ, Rintoul RC, Francies HE, Marciniak SJ. Shamseddin M, et al. Among authors: obacz j. Thorax. 2021 Nov;76(11):1154-1162. doi: 10.1136/thoraxjnl-2020-216602. Epub 2021 Mar 10. Thorax. 2021. PMID: 33692175 Free PMC article. Review.
20 results