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The liquid-to-solid transition of FUS is promoted by the condensate surface.
Shen Y, Chen A, Wang W, Shen Y, Ruggeri FS, Aime S, Wang Z, Qamar S, Espinosa JR, Garaizar A, St George-Hyslop P, Collepardo-Guevara R, Weitz DA, Vigolo D, Knowles TPJ. Shen Y, et al. Among authors: knowles tpj. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2301366120. doi: 10.1073/pnas.2301366120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549257 Free PMC article.
Observation of spatial propagation of amyloid assembly from single nuclei.
Knowles TP, White DA, Abate AR, Agresti JJ, Cohen SI, Sperling RA, De Genst EJ, Dobson CM, Weitz DA. Knowles TP, et al. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14746-51. doi: 10.1073/pnas.1105555108. Epub 2011 Aug 26. Proc Natl Acad Sci U S A. 2011. PMID: 21876182 Free PMC article.
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, Saibil HR, Vendruscolo M, Orlova EV, Griffin RG, Dobson CM. Fitzpatrick AW, et al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5468-73. doi: 10.1073/pnas.1219476110. Epub 2013 Mar 19. Proc Natl Acad Sci U S A. 2013. PMID: 23513222 Free PMC article.
Protein microgels from amyloid fibril networks.
Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Linse S, Åkerfeldt KS, Dobson CM, Weitz DA, Knowles TP. Shimanovich U, et al. ACS Nano. 2015 Jan 27;9(1):43-51. doi: 10.1021/nn504869d. Epub 2015 Jan 12. ACS Nano. 2015. PMID: 25469621
Fluctuations in the Kinetics of Linear Protein Self-Assembly.
Michaels TC, Dear AJ, Kirkegaard JB, Saar KL, Weitz DA, Knowles TP. Michaels TC, et al. Phys Rev Lett. 2016 Jun 24;116(25):258103. doi: 10.1103/PhysRevLett.116.258103. Epub 2016 Jun 21. Phys Rev Lett. 2016. PMID: 27391756
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D. Iljina M, et al. Among authors: knowles tpj. BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6. BMC Biol. 2017. PMID: 28673288 Free PMC article.
Silk micrococoons for protein stabilisation and molecular encapsulation.
Shimanovich U, Ruggeri FS, De Genst E, Adamcik J, Barros TP, Porter D, Müller T, Mezzenga R, Dobson CM, Vollrath F, Holland C, Knowles TPJ. Shimanovich U, et al. Among authors: knowles tpj. Nat Commun. 2017 Jul 19;8:15902. doi: 10.1038/ncomms15902. Nat Commun. 2017. PMID: 28722016 Free PMC article.
390 results