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Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms.
Grockowiak E, Korn C, Rak J, Lysenko V, Hallou A, Panvini FM, Williams M, Fielding C, Fang Z, Khatib-Massalha E, García-García A, Li J, Khorshed RA, González-Antón S, Baxter EJ, Kusumbe A, Wilkins BS, Green A, Simons BD, Harrison CN, Green AR, Lo Celso C, Theocharides APA, Méndez-Ferrer S. Grockowiak E, et al. Among authors: khatib massalha e. Nat Cancer. 2023 Aug;4(8):1193-1209. doi: 10.1038/s43018-023-00607-x. Epub 2023 Aug 7. Nat Cancer. 2023. PMID: 37550517 Free PMC article.
Lactate-a new player in G-CSF-induced mobilization of hematopoietic stem/progenitor cells.
Ordonez-Moreno LA, Haddad M, Chakrabarti P, Khatib-Massalha E, Fruchtman H, Boura-Halfon S, Petrovich-Kopitman E, Lapidot T, Kollet O. Ordonez-Moreno LA, et al. Among authors: khatib massalha e. Leukemia. 2023 Aug;37(8):1757-1761. doi: 10.1038/s41375-023-01917-w. Epub 2023 May 3. Leukemia. 2023. PMID: 37138018 No abstract available.
Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation.
Biram A, Liu J, Hezroni H, Davidzohn N, Schmiedel D, Khatib-Massalha E, Haddad M, Grenov A, Lebon S, Salame TM, Dezorella N, Hoffman D, Abou Karam P, Biton M, Lapidot T, Bemark M, Avraham R, Jung S, Shulman Z. Biram A, et al. Among authors: khatib massalha e. Immunity. 2022 Mar 8;55(3):442-458.e8. doi: 10.1016/j.immuni.2022.01.013. Epub 2022 Feb 18. Immunity. 2022. PMID: 35182483 Free article.
Enhanced thrombin/PAR1 activity promotes G-CSF- and AMD3100-induced mobilization of hematopoietic stem and progenitor cells via NO upregulation.
Nevo N, Ordonez-Moreno LA, Gur-Cohen S, Avemaria F, Bhattacharya S, Khatib-Massalha E, Bertagna M, Haddad M, Chakrabarti P, Ruf W, Lapidot T, Kollet O. Nevo N, et al. Among authors: khatib massalha e. Leukemia. 2021 Nov;35(11):3334-3338. doi: 10.1038/s41375-021-01194-5. Epub 2021 Mar 2. Leukemia. 2021. PMID: 33654208 No abstract available.
The doctor prescribed a fat-free diet for stem cell mobilization.
Kollet O, Khatib-Massalha E, Lapidot T. Kollet O, et al. Among authors: khatib massalha e. Haematologica. 2021 Jun 1;106(6):1512-1513. doi: 10.3324/haematol.2020.278239. Haematologica. 2021. PMID: 33538158 Free PMC article. No abstract available.
Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma.
Golan K, Singh AK, Kollet O, Bertagna M, Althoff MJ, Khatib-Massalha E, Petrovich-Kopitman E, Wellendorf AM, Massalha H, Levin-Zaidman S, Dadosh T, Bohan B, V Gawali M, Dasgupta B, Lapidot T, Cancelas JA. Golan K, et al. Among authors: khatib massalha e. Blood. 2020 Dec 3;136(23):2607-2619. doi: 10.1182/blood.2020005399. Blood. 2020. PMID: 32929449 Free PMC article.
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling.
Khatib-Massalha E, Bhattacharya S, Massalha H, Biram A, Golan K, Kollet O, Kumari A, Avemaria F, Petrovich-Kopitman E, Gur-Cohen S, Itkin T, Brandenburger I, Spiegel A, Shulman Z, Gerhart-Hines Z, Itzkovitz S, Gunzer M, Offermanns S, Alon R, Ariel A, Lapidot T. Khatib-Massalha E, et al. Nat Commun. 2020 Jul 15;11(1):3547. doi: 10.1038/s41467-020-17402-2. Nat Commun. 2020. PMID: 32669546 Free PMC article.
Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.
Golan K, Kumari A, Kollet O, Khatib-Massalha E, Subramaniam MD, Ferreira ZS, Avemaria F, Rzeszotek S, García-García A, Xie S, Flores-Figueroa E, Gur-Cohen S, Itkin T, Ludin-Tal A, Massalha H, Bernshtein B, Ciechanowicz AK, Brandis A, Mehlman T, Bhattacharya S, Bertagna M, Cheng H, Petrovich-Kopitman E, Janus T, Kaushansky N, Cheng T, Sagi I, Ratajczak MZ, Méndez-Ferrer S, Dick JE, Markus RP, Lapidot T. Golan K, et al. Among authors: khatib massalha e. Cell Stem Cell. 2018 Oct 4;23(4):572-585.e7. doi: 10.1016/j.stem.2018.08.002. Epub 2018 Aug 30. Cell Stem Cell. 2018. PMID: 30174297 Free article.
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