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Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms.
Grockowiak E, Korn C, Rak J, Lysenko V, Hallou A, Panvini FM, Williams M, Fielding C, Fang Z, Khatib-Massalha E, García-García A, Li J, Khorshed RA, González-Antón S, Baxter EJ, Kusumbe A, Wilkins BS, Green A, Simons BD, Harrison CN, Green AR, Lo Celso C, Theocharides APA, Méndez-Ferrer S. Grockowiak E, et al. Among authors: theocharides apa. Nat Cancer. 2023 Aug;4(8):1193-1209. doi: 10.1038/s43018-023-00607-x. Epub 2023 Aug 7. Nat Cancer. 2023. PMID: 37550517 Free PMC article.
Humanized hemato-lymphoid system mice.
Theocharides AP, Rongvaux A, Fritsch K, Flavell RA, Manz MG. Theocharides AP, et al. Haematologica. 2016 Jan;101(1):5-19. doi: 10.3324/haematol.2014.115212. Haematologica. 2016. PMID: 26721800 Free PMC article. Review.
The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14.
Drexler B, Passweg JR, Tzankov A, Bigler M, Theocharides AP, Cantoni N, Keller P, Stussi G, Ruefer A, Benz R, Favre G, Lundberg P, Nienhold R, Fuhrer A, Biaggi C, Manz MG, Bargetzi M, Mendez-Ferrer S, Skoda RC; Swiss Group for Clinical Cancer Research (SAKK). Drexler B, et al. Haematologica. 2019 Apr;104(4):710-716. doi: 10.3324/haematol.2018.200014. Epub 2018 Nov 8. Haematologica. 2019. PMID: 30409796 Free PMC article. Clinical Trial.
Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice.
Lysenko V, Wildner-Verhey van Wijk N, Zimmermann K, Weller MC, Bühler M, Wildschut MHE, Schürch P, Fritz C, Wagner U, Calabresi L, Psaila B, Flavell RA, Vannucchi AM, Mead AJ, Wild PJ, Dirnhofer S, Manz MG, Theocharides APA. Lysenko V, et al. Among authors: theocharides apa. Blood Adv. 2020 Jun 9;4(11):2477-2488. doi: 10.1182/bloodadvances.2019001364. Blood Adv. 2020. PMID: 32502268 Free PMC article.
A patient with a germline GATA2 mutation and primary myelofibrosis.
Rütsche CV, Haralambieva E, Lysenko V, Balabanov S, Theocharides APA. Rütsche CV, et al. Among authors: theocharides apa. Blood Adv. 2021 Feb 9;5(3):791-795. doi: 10.1182/bloodadvances.2020003401. Blood Adv. 2021. PMID: 33560389 Free PMC article.
Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis.
Wildschut MHE, Mena J, Dördelmann C, van Oostrum M, Hale BD, Settelmeier J, Festl Y, Lysenko V, Schürch PM, Ring A, Severin Y, Bader MS, Pedrioli PGA, Goetze S, van Drogen A, Balabanov S, Skoda RC, Lopes M, Wollscheid B, Theocharides APA, Snijder B. Wildschut MHE, et al. Among authors: theocharides apa. Nat Commun. 2023 Oct 12;14(1):6414. doi: 10.1038/s41467-023-42101-z. Nat Commun. 2023. PMID: 37828014 Free PMC article.
Humanised mouse models for haematopoiesis and infectious diseases.
Lysenko V, McHugh D, Behrmann L, Rochat MA, Wilk CM, Kovtonyuk L, Bourquin JP, Münz C, Manz MG, Speck R, Theocharides A. Lysenko V, et al. Swiss Med Wkly. 2017 Oct 22;147:w14516. doi: 10.4414/smw.2017.14516. eCollection 2017. Swiss Med Wkly. 2017. PMID: 29120027 Free article. Review.
47 results