Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.
Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, Tall AR, Kathiresan S, Fisher EA, Musunuru K, Rader DJ.
Strong A, et al.
J Clin Invest. 2012 Aug;122(8):2807-16. doi: 10.1172/JCI63563. Epub 2012 Jul 2.
J Clin Invest. 2012.
PMID: 22751103
Free PMC article.
Genome-wide association studies (GWAS) have identified a genetic variant at a locus on chromosome 1p13 that is associated with reduced risk of myocardial infarction, reduced plasma levels of LDL cholesterol (LDL-C), and markedly increased expression of the gene sort …
Genome-wide association studies (GWAS) have identified a genetic variant at a locus on chromosome 1p13 that is associated with …