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IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding.
Bolton MJ, Santos JJS, Arevalo CP, Griesman T, Watson M, Li SH, Bates P, Ramage H, Wilson PC, Hensley SE. Bolton MJ, et al. Among authors: hensley se. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2216521120. doi: 10.1073/pnas.2216521120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603748 Free PMC article.
Immune history shapes specificity of pandemic H1N1 influenza antibody responses.
Li Y, Myers JL, Bostick DL, Sullivan CB, Madara J, Linderman SL, Liu Q, Carter DM, Wrammert J, Esposito S, Principi N, Plotkin JB, Ross TM, Ahmed R, Wilson PC, Hensley SE. Li Y, et al. Among authors: hensley se. J Exp Med. 2013 Jul 29;210(8):1493-500. doi: 10.1084/jem.20130212. Epub 2013 Jul 15. J Exp Med. 2013. PMID: 23857983 Free PMC article.
Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.
Linderman SL, Chambers BS, Zost SJ, Parkhouse K, Li Y, Herrmann C, Ellebedy AH, Carter DM, Andrews SF, Zheng NY, Huang M, Huang Y, Strauss D, Shaz BH, Hodinka RL, Reyes-Terán G, Ross TM, Wilson PC, Ahmed R, Bloom JD, Hensley SE. Linderman SL, et al. Among authors: hensley se. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15798-803. doi: 10.1073/pnas.1409171111. Epub 2014 Oct 20. Proc Natl Acad Sci U S A. 2014. PMID: 25331901 Free PMC article. Clinical Trial.
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.
Zost SJ, Parkhouse K, Gumina ME, Kim K, Diaz Perez S, Wilson PC, Treanor JJ, Sant AJ, Cobey S, Hensley SE. Zost SJ, et al. Among authors: hensley se. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12578-12583. doi: 10.1073/pnas.1712377114. Epub 2017 Nov 6. Proc Natl Acad Sci U S A. 2017. PMID: 29109276 Free PMC article.
Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.
Henry C, Zheng NY, Huang M, Cabanov A, Rojas KT, Kaur K, Andrews SF, Palm AE, Chen YQ, Li Y, Hoskova K, Utset HA, Vieira MC, Wrammert J, Ahmed R, Holden-Wiltse J, Topham DJ, Treanor JJ, Ertl HC, Schmader KE, Cobey S, Krammer F, Hensley SE, Greenberg H, He XS, Wilson PC. Henry C, et al. Among authors: hensley se. Cell Host Microbe. 2019 Mar 13;25(3):357-366.e6. doi: 10.1016/j.chom.2019.01.002. Epub 2019 Feb 19. Cell Host Microbe. 2019. PMID: 30795982 Free PMC article.
Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions.
Mathew D, Giles JR, Baxter AE, Greenplate AR, Wu JE, Alanio C, Oldridge DA, Kuri-Cervantes L, Pampena MB, D'Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, Ittner CAG, Kuthuru O, Dougherty J, Nzingha K, Han N, Kim J, Pattekar A, Goodwin EC, Anderson EM, Weirick ME, Gouma S, Arevalo CP, Bolton MJ, Chen F, Lacey SF, Hensley SE, Apostolidis S, Huang AC, Vella LA; UPenn COVID Processing Unit; Betts MR, Meyer NJ, Wherry EJ. Mathew D, et al. Among authors: hensley se. bioRxiv [Preprint]. 2020 May 23:2020.05.20.106401. doi: 10.1101/2020.05.20.106401. bioRxiv. 2020. PMID: 32511371 Free PMC article. Updated. Preprint.
143 results