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Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.
Hudaiberdiev S, Taylor DL, Song W, Narisu N, Bhuiyan RM, Taylor HJ, Tang X, Yan T, Swift AJ, Bonnycastle LL, Consortium D, Chen S, Stitzel ML, Erdos MR, Ovcharenko I, Collins FS. Hudaiberdiev S, et al. Among authors: chen s. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2206612120. doi: 10.1073/pnas.2206612120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603758 Free PMC article.
SARS-CoV-2 infection induces beta cell transdifferentiation.
Tang X, Uhl S, Zhang T, Xue D, Li B, Vandana JJ, Acklin JA, Bonnycastle LL, Narisu N, Erdos MR, Bram Y, Chandar V, Chong ACN, Lacko LA, Min Z, Lim JK, Borczuk AC, Xiang J, Naji A, Collins FS, Evans T, Liu C, tenOever BR, Schwartz RE, Chen S. Tang X, et al. Among authors: chen s. Cell Metab. 2021 Aug 3;33(8):1577-1591.e7. doi: 10.1016/j.cmet.2021.05.015. Epub 2021 May 19. Cell Metab. 2021. PMID: 34081913 Free PMC article.
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Nok Chong AC, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhong A, Bonnycastle LL, Zhou T, Chen S, Collins FS. Xue D, et al. Among authors: chen s. Cell Metab. 2023 Nov 7;35(11):1897-1914.e11. doi: 10.1016/j.cmet.2023.09.013. Epub 2023 Oct 18. Cell Metab. 2023. PMID: 37858332 Free article.
An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals.
Zhao Z, D'Oliveira Albanus R, Taylor H, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, Erdos M, Narisu N, Taylor L, Saavedra X, Zhong A, Li B, Zhou T, Naji A, Liu C, Collins F, Parker SC, Chen S. Zhao Z, et al. Among authors: chen s. Res Sq [Preprint]. 2023 Oct 18:rs.3.rs-3343318. doi: 10.21203/rs.3.rs-3343318/v1. Res Sq. 2023. PMID: 37886586 Free PMC article. Preprint.
Generation of pluripotent stem cells from patients with type 1 diabetes.
Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Maehr R, et al. Among authors: chen s. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15768-73. doi: 10.1073/pnas.0906894106. Epub 2009 Aug 31. Proc Natl Acad Sci U S A. 2009. PMID: 19720998 Free PMC article.
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection.
Tang X, Xue D, Zhang T, Nilsson-Payant BE, Carrau L, Duan X, Gordillo M, Tan AY, Qiu Y, Xiang J, Schwartz RE, tenOever BR, Evans T, Chen S. Tang X, et al. Among authors: chen s. Nat Cell Biol. 2023 Mar;25(3):381-389. doi: 10.1038/s41556-023-01095-y. Epub 2023 Mar 13. Nat Cell Biol. 2023. PMID: 36918693 Free PMC article.
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