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Aging impairs the neurovascular interface in the heart.
Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J, Kujundzic H, Manickam N, Schmitz K, Cipca M, Stilz KA, Fischer A, Muhly-Reinholz M, Abplanalp WT, John D, Mohanta SK, Weber C, Habenicht AJR, Buchmann GK, Angendohr S, Amin E, Scherschel K, Klöcker N, Kelm M, Schüttler D, Clauss S, Günther S, Boettger T, Braun T, Bär C, Pham MD, Krishnan J, Hille S, Müller OJ, Bozoglu T, Kupatt C, Nardini E, Osmanagic-Myers S, Meyer C, Zeiher AM, Brandes RP, Luxán G, Dimmeler S. Wagner JUG, et al. Among authors: luxan g. Science. 2023 Aug 25;381(6660):897-906. doi: 10.1126/science.ade4961. Epub 2023 Aug 24. Science. 2023. PMID: 37616346
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.
Luxán G, Casanova JC, Martínez-Poveda B, Prados B, D'Amato G, MacGrogan D, Gonzalez-Rajal A, Dobarro D, Torroja C, Martinez F, Izquierdo-García JL, Fernández-Friera L, Sabater-Molina M, Kong YY, Pizarro G, Ibañez B, Medrano C, García-Pavía P, Gimeno JR, Monserrat L, Jiménez-Borreguero LJ, de la Pompa JL. Luxán G, et al. Nat Med. 2013 Feb;19(2):193-201. doi: 10.1038/nm.3046. Epub 2013 Jan 13. Nat Med. 2013. PMID: 23314057
Sequential Notch activation regulates ventricular chamber development.
D'Amato G, Luxán G, del Monte-Nieto G, Martínez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jiménez-Borreguero LJ, de la Pompa JL. D'Amato G, et al. Among authors: luxan g. Nat Cell Biol. 2016 Jan;18(1):7-20. doi: 10.1038/ncb3280. Epub 2015 Dec 7. Nat Cell Biol. 2016. PMID: 26641715 Free PMC article.
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes.
Bojkova D, Wagner JUG, Shumliakivska M, Aslan GS, Saleem U, Hansen A, Luxán G, Günther S, Pham MD, Krishnan J, Harter PN, Ermel UH, Frangakis AS, Milting H, Zeiher AM, Klingel K, Cinatl J, Dendorfer A, Eschenhagen T, Tschöpe C, Ciesek S, Dimmeler S. Bojkova D, et al. Among authors: luxan g. Cardiovasc Res. 2020 Dec 1;116(14):2207-2215. doi: 10.1093/cvr/cvaa267. Cardiovasc Res. 2020. PMID: 32966582 Free PMC article.
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction.
Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S. Tombor LS, et al. Among authors: luxan g. Nat Commun. 2021 Jan 29;12(1):681. doi: 10.1038/s41467-021-20905-1. Nat Commun. 2021. PMID: 33514719 Free PMC article.
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