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A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.
Gall L, Jardi F, Lammens L, Piñero J, Souza TM, Rodrigues D, Jennen DGJ, de Kok TM, Coyle L, Chung SW, Ferreira S, Jo H, Beattie KA, Kelly C, Duckworth CA, Pritchard DM, Pin C. Gall L, et al. Among authors: jardi f. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1511-1528. doi: 10.1002/psp4.13029. Epub 2023 Sep 11. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37621010 Free PMC article.
Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules.
Kourula S, Derksen M, Jardi F, Jonkers S, van Heerden M, Verboven P, Theuns V, Van Asten S, Huybrechts T, Kunze A, Frazer-Mendelewska E, Lai KW, Overmeer R, Roos JL, Vries RGJ, Boj SF, Monshouwer M, Pourfarzad F, Snoeys J. Kourula S, et al. Among authors: jardi f. Eur J Pharm Sci. 2023 Sep 1;188:106481. doi: 10.1016/j.ejps.2023.106481. Epub 2023 May 25. Eur J Pharm Sci. 2023. PMID: 37244450 Free article.
Estrogen receptor alpha signaling in extrahypothalamic neurons during late puberty decreases bone size and strength in female but not in male mice.
Kim NR, Jardí F, Khalil R, Antonio L, Schollaert D, Deboel L, van Lenthe GH, Decallonne B, Carmeliet G, Gustafsson JÅ, Claessens F, Ohlsson C, Lagerquist MK, Dubois V, Vanderschueren D. Kim NR, et al. Among authors: jardi f. FASEB J. 2020 May;34(5):7118-7126. doi: 10.1096/fj.202000272R. Epub 2020 Apr 2. FASEB J. 2020. PMID: 32239553
Androgen Receptor in Neurons Slows Age-Related Cortical Thinning in Male Mice.
Jardí F, Kim N, Laurent MR, Khalil R, Deboel L, Schollaert D, van Lenthe GH, Decallonne B, Carmeliet G, Claessens F, Vanderschueren D. Jardí F, et al. J Bone Miner Res. 2019 Mar;34(3):508-519. doi: 10.1002/jbmr.3625. Epub 2019 Jan 15. J Bone Miner Res. 2019. PMID: 30496619 Free article.
26 results