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A loss-of-function CCR2 variant is associated with lower cardiovascular risk.
Georgakis MK, Malik R, Bounkari OE, Hasbani NR, Li J, Huffman JE, Shakt G, Tack RWP, Kimball TN, Asare Y, Morrison AC, Tsao NL, Judy R, Mitchell BD, Xu H, Montasser ME, Do R, Kenny EE, Loos RJF, Terry JG, Carr JJ, Bis JC, Psaty BM, Longstreth WT, Young KA, Lutz SM, Cho MH, Broome J, Khan AT, Wang FF, Heard-Costa N, Seshadri S, Vasan RS, Palmer ND, Freedman BI, Bowden DW, Yanek LR, Kral BG, Becker LC, Peyser PA, Bielak LF, Ammous F, Carson AP, Hall ME, Raffield LM, Rich SS, Post WS, Tracy RP, Taylor KD, Guo X, Mahaney MC, Curran JE, Blangero J, Clarke SL, Haessler JW, Hu Y, Assimes TL, Kooperberg C, Bernhagen J, Anderson CD, Damrauer SM, Zand R, Rotter JI, de Vries PS, Dichgans M. Georgakis MK, et al. Among authors: asare y. medRxiv [Preprint]. 2024 May 6:2023.08.14.23294063. doi: 10.1101/2023.08.14.23294063. medRxiv. 2024. PMID: 37645892 Free PMC article. Preprint.
IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses.
Asare Y, Shnipova M, Živković L, Schlegl C, Tosato F, Aronova A, Brandhofer M, Strohm L, Beaufort N, Malik R, Weber C, Bernhagen J, Dichgans M. Asare Y, et al. Signal Transduct Target Ther. 2022 Oct 19;7(1):355. doi: 10.1038/s41392-022-01189-3. Signal Transduct Target Ther. 2022. PMID: 36257930 Free PMC article. No abstract available.
Epidemiology and Outcomes of Hospitalizations Due to Hepatocellular Carcinoma.
Mullangi S, Keesari PR, Zaher A, Pulakurthi YS, Adusei Poku F, Rajeev A, Vidiyala PL, Guntupalli AL, Desai M, Ohemeng-Dapaah J, Asare Y, Patel AA, Lekkala M. Mullangi S, et al. Among authors: asare y. Cureus. 2021 Dec 1;13(12):e20089. doi: 10.7759/cureus.20089. eCollection 2021 Dec. Cureus. 2021. PMID: 35003948 Free PMC article.
Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability.
Georgakis MK, van der Laan SW, Asare Y, Mekke JM, Haitjema S, Schoneveld AH, de Jager SCA, Nurmohamed NS, Kroon J, Stroes ESG, de Kleijn DPV, de Borst GJ, Maegdefessel L, Soehnlein O, Pasterkamp G, Dichgans M. Georgakis MK, et al. Among authors: asare y. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):2038-2048. doi: 10.1161/ATVBAHA.121.316091. Epub 2021 Apr 8. Arterioscler Thromb Vasc Biol. 2021. PMID: 33827260
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A. Roth S, et al. Among authors: asare y. Immunity. 2021 Apr 13;54(4):648-659.e8. doi: 10.1016/j.immuni.2021.02.004. Epub 2021 Mar 4. Immunity. 2021. PMID: 33667383 Free article.
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.
Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J. Kontos C, et al. Among authors: asare y. Nat Commun. 2020 Nov 25;11(1):5981. doi: 10.1038/s41467-020-19764-z. Nat Commun. 2020. PMID: 33239628 Free PMC article.
27 results