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A systems approach reveals species differences in hepatic stress response capacity.
Russomanno G, Sison-Young R, Livoti LA, Coghlan H, Jenkins RE, Kunnen SJ, Fisher CP, Reddyhoff D, Gardner I, Rehman AH, Fenwick SW, Jones AR, Vermeil De Conchard G, Simonin G, Bertheux H, Weaver RJ, Johnson RL, Liguori MJ, Clausznitzer D, Stevens JL, Goldring CE, Copple IM. Russomanno G, et al. Among authors: coghlan h. Toxicol Sci. 2023 Oct 30;196(1):112-125. doi: 10.1093/toxsci/kfad085. Toxicol Sci. 2023. PMID: 37647630 Free PMC article.
Mechanistic in vitro studies indicate that the clinical drug-drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3.
Elsby R, Coghlan H, Edgerton J, Hodgson D, Outteridge S, Atkinson H. Elsby R, et al. Among authors: coghlan h. Pharmacol Res Perspect. 2023 Apr;11(2):e01060. doi: 10.1002/prp2.1060. Pharmacol Res Perspect. 2023. PMID: 36811234 Free PMC article.
Left ventricular form and function: scientific priorities and strategic planning for development of new views of disease.
Buckberg GD, Weisfeldt ML, Ballester M, Beyar R, Burkhoff D, Coghlan HC, Doyle M, Epstein ND, Gharib M, Ideker RE, Ingels NB, LeWinter MM, McCulloch AD, Pohost GM, Reinlib LJ, Sahn DJ, Sopko G, Spinale FG, Spotnitz HM, Torrent-Guasp F, Shapiro EP. Buckberg GD, et al. Among authors: coghlan hc. Circulation. 2004 Oct 5;110(14):e333-6. doi: 10.1161/01.CIR.0000143625.56882.5C. Circulation. 2004. PMID: 15466651 No abstract available.
34 results